Fumonisin

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A fumonisin is a mycotoxin derived from Fusarium.[1]

More specifically, it can refer to:

The trichothecene (T-2) mycotoxins are a group of over 40 compounds produced by fungi of the genus Fusarium, a common grain mold.[2]

The estrogenic metabolite, zearalenone, is also referred to as F-2 toxin.[3]

As the fumonisins appear to be non-genotoxic the possibility that they belong to another class of non-genotoxic carcinogens, the peroxisome proliferators, was investigated[4]

Genetic engineering is reported as a promising means of detoxifying mycotoxins. This approach may provide innovative solutions to the problem of fumonisin in corn.[5]

At least 15 different fumonisins have so far been reported and other minor metabolites have been identified, although most of them have not been shown to occur naturally.[6]

References[edit]

  1. ^ Fumonisins at the US National Library of Medicine Medical Subject Headings (MeSH)
  2. ^ USAMRIID's Medical Management of Biological Casualties Handbook, 6th Ed. McLean, VA: International Medical Publishing, Inc. 2005. pp. 102–103. ISBN 1-58808-162-1. 
  3. ^ Marasas, W.F.O.; Paul E. Nelson (1987). Mycotoxicology: Introduction to the Mycology, Plant Pathology, Chemistry, Toxicology, and Pathology of Naturally Occurring Mycotoxicoses In Animals and Man. University Park, PA: The Pennsylvania State University Press. p. 47. ISBN 0-271-00442-8. 
  4. ^ Jackson, Lauren S.; Jonathan W. DeVries; Lloyd B. Bullerman (1996). Fumonisins In Food. New York, NY: Plenum Press. p. 289. ISBN 0-306-45216-2. 
  5. ^ "Reduced contamination by the Fusarium mycotoxin zearalenone in maize kernels through genetic modification with a detoxification gene.". Appl Environ Microbiol 73 (5): 1622–9. March 2007. doi:10.1128/aem.01077-06. 
  6. ^ Marasas, W.F.O.; J.D. Miller, R.T. Riley, A. Visconti (2000). Environmental Health Criteria 219: Fumonisin B1. Vammala, Finland: World Health Organization. p. 9. ISBN 92-4-157219-1.