Fundic glands

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Fundic glands
Fundic gland polyp (1).jpg
H&E stain of fundic gland polyp showing shortening of the gastric pits with cystic dilatation
Latin glandulae gastricae
Gray's p.1166

The fundus glands (or fundic glands, or gastric glandsor oxyntic glands) are found in the body, the gastric mucosa, and fundus of the stomach.

They are simple tubes, two or more of which open into a single duct.

Pathology[edit]

Fundic gland polyposis is a medical syndrome where the fundus of the stomach develops many polyps.

Types of cells[edit]

Location Name Description Secretion Staining
Isthmus Mucous neck cells In gastric pits. mucus gel layer Clear
Neck parietal (oxyntic) cells Between the chief cells and the basement membrane, larger oval cells, which stain deeply with eosin, are found; these cells are studded throughout the tube at intervals, giving it a beaded or varicose appearance. These are known as the parietal cells or oxyntic cells, and they are connected with the lumen by fine channels which run into their substance. gastric acid and intrinsic factor Acidophilic
Base chief (zymogenic) cells At the point where they open into the duct, which is termed the neck, the epithelium alters, and consists of short columnar or polyhedral, granular cells, which almost fill the tube, so that the lumen becomes suddenly constricted and is continued down as a very fine channel. They are known as the chief cells or central cells of the glands. pepsinogen, rennin Basophilic
Base enteroendocrine (APUD) cells G cells are a type of enteroendocrine cell that secrete the hormone gastrin (gastrin promotes the secretion of pepsinogen (by chief cells) and HCl (by parietal cells) and promotes gastric contractions to mix contents). hormones -

Additional images[edit]

External links[edit]

This article incorporates text from a public domain edition of Gray's Anatomy.