Funding of science

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Research funding is a term generally covering any funding for scientific research, in the areas of both "hard" science and technology and social science. The term often connotes funding obtained through a competitive process, in which potential research projects are evaluated and only the most promising receive funding. Such processes, which are run by government, corporations or foundations, allocate scarce funds.

Most research funding comes from two major sources, corporations (through research and development departments) and government (primarily carried out through universities and specialized government agencies). Some small amounts of scientific research are carried out (or funded) by charitable foundations, especially in relation to developing cures for diseases such as cancer, malaria and AIDS.[citation needed]

According to OECD, around two-thirds of research and development in scientific and technical fields is carried out by industries, and 20% and 10% respectively by universities and government[citation needed]. Comparatively, in countries with less GDP, such as Portugal and Mexico the industry contribution is significantly lower. The US government spends more than other countries on military R&D, although the proportion has fallen from around 30% in the 1980s to under 20[citation needed]. Government funding for medical research amounts to approximately 36% in the U.S. The government funding proportion in certain industries is higher, and it dominates research in social science and humanities. Similarly, with some exceptions (e.g. biotechnology) government provides the bulk of the funds for basic scientific research.[citation needed] In commercial research and development, all but the most research-oriented corporations focus more heavily on near-term commercialization possibilities rather than "blue-sky" ideas or technologies (such as nuclear fusion).[1]

Government-funded research[edit]

Main article: Science policy

Government-funded research can either be carried out by the government itself, or through grants to academic and other researchers outside the government.[citation needed]

Critics[who?] of basic research are concerned that research funding for the sake of knowledge itself does not contribute to a great return. However, scientific innovations often foreshadow or inspire further ideas unintentionally. For example, NASA's quest to put a man on the moon inspired them to develop better sound recording and reading technologies. NASA's research was furthered by the music industry, who used it to develop audio cassettes. Audio cassettes, being smaller and able to store more music, quickly dominated the music industry and increased the availability of music.[citation needed]

An additional distinction of government-sponsored research is that the government does not make a claim to the intellectual property, whereas private research-funding bodies sometimes claim ownership of the intellectual property that they are paying to have developed. Consequently, government-sponsored research more often allows the individual discoverer to file intellectual property claims over their own work.[citation needed]

Privately funded research[edit]

Private funding for research comes from philanthropists,[2] crowd-funding,[3] private companies, non-profit foundations, and professional organizations.[4] Philanthropists and foundations have been known to pour millions of dollars into a wide variety of scientific investigations, including basic research discovery, disease cures, particle physics, astronomy, marine science, and the environment.[2] Many large technology companies spend billions of dollars on research and development each year to gain an innovative advantage over their competitors, though only about 42% of this funding goes towards projects that are considered substantially new, or capable of yielding radical breakthroughs.[5] New scientific start-up companies initially seek funding from crowd-funding organizations, venture capitalists, and angel investors, gathering preliminary results using Rent-A-Lab facilities,[6] but aim to eventually become self-sufficient.[3][7]

Examples of companies that fund basic research include IBM (high temperature superconductivity was discovered by IBM sponsored basic experimental research in 1986), L'Oreal (which created the L'Oreal-Unesco prize for women scientists and finances internships), AXA (which launched a Research Fund in 2008 and finances Academic Institutions such as advanced fundamental mathematics French Foundation IHES), e.g.

An often-quoted case study is the first sequencing of the human genome, which was simultaneously carried out in two competing projects, the United States government-managed Human Genome Project (HGP) and the private venture capital funded Celera Genomics. Celera Genomics used a newer, albeit riskier technique, which some HGP researchers[who?] claimed would not work, although that project eventually adopted some of the same methods. However, it has been argued by some genomics researchers that a simple efficiency comparison for such programs is not apt. Much of the funding provided for the HGP served the development of new technologies, rather than the sequencing of the human genome itself. In addition, Celera started much later than the HGP and could take advantage of the experience gained by the HGP, which, as a publicly funded project, made much of its work available as a basis upon which Celera could build. Though Celera's sequencing strategy allowed the sequencing of the majority of the human genome with much higher efficacy, the strategy used by the HGP allowed the sequencing of a higher percentage of the genome.[citation needed]

Research funding process[edit]

Often scientists apply for research funding which a granting agency may (or may not) approve to financially support. These grants require a lengthy process as the granting agency can inquire about the researcher(s)'s background, the facilities used, the equipment needed, the time involved, and the overall potential of the scientific outcome. The process of grant writing and grant proposing is a somewhat delicate process for both the grantor and the grantee: the grantors want to choose the research that best fits their scientific principles, and the individual grantees want to apply for research in which they have the best chances but also in which they can build a body of work towards future scientific endeavours. This interplay can become a frustrating and lengthy process.[citation needed]

The Engineering and Physical Sciences Research Council in the United Kingdom has devised an alternative method of fund-distribution: the sandpit.[8]

Most universities have research administration offices to facilitate the interaction between the researcher and the granting agency.[9] "Research administration is all about service—service to our faculty, to our academic units, to the institution, and to our sponsors. To be of service, we first have to know what our customers want and then determine whether or not we are meeting those needs and expectations.” [10]

In the United States of America, the National Council of University Research Administrators (NCURA) serves its members and advances the field of research administration through education and professional development programs, the sharing of knowledge and experience, and by fostering a professional, collegial, and respected community.

Funding influence on research[edit]

The source of funding may introduce conscious or unconscious biases into a researcher's work.[11] Disclosure of potential conflicts of interest (COIs) is used by biomedical journals to guarantee credibility and transparency of the scientific process. Conflict of interest disclosure, however, is not systematically nor consistently dealt with by journals which publish scientific research results. When research is funded by the same agency that can be expected to gain from a favorable outcome there is a potential for biased results and research shows that results are indeed more favorable than would be expected from a more objective view of the evidence. A 2003 systematic review studied the scope and impact of industry sponsorship in biomedical research. The researchers found financial relationships among industry, scientific investigators, and academic institutions widespread. Results showed a statistically significant association between industry sponsorship and pro-industry conclusions and concluded that "Conflicts of interest arising from these ties can influence biomedical research in important ways".[12] A British study found that a majority of the members on national and food policy committees receive funding from food companies.[13]

In an effort to cut costs, the pharmaceutical industry has turned to the use of private, nonacademic research groups (i.e., contract research organizations [CROs]) which can do the work for less money than academic investigators. In 2001 CROs came under criticism when the editors of 12 major scientific journals issued a joint editorial, published in each journal, on the control over clinical trials exerted by sponsors, particularly targeting the use of contracts which allow sponsors to review the studies prior to publication and withhold publication of any studies in which their product did poorly. They further criticized the trial methodology stating that researchers are frequently restricted from contributing to the trial design, accessing the raw data, and interpreting the results.[14]

The Cochrane Collaboration, a world-wide group that aims to provide compiled scientific evidence to aid well informed health care decisions, conducts systematic reviews of randomized controlled trials of health care interventions and tries to disseminate the results and conclusions derived from them.[15][16] A few more recent reviews have also studied the results of non-randomized, observational studies. The systematic reviews are published in the Cochrane Library. A 2011 study done to disclose possible conflicts of interests [COI] in underlying research studies used for medical meta-analyses reviewed 29 meta-analyses and found that COIs in the studies underlying the meta-analyses were rarely disclosed. The 29 meta-analyses reviewed an aggregate of 509 randomized controlled trials (RCTs). Of these, 318 RCTs reported funding sources with 219 (69%) industry funded. 132 of the 509 RCTs reported author COI disclosures, with 91 studies (69%) disclosing industry financial ties with one or more authors. The information was, however, seldom reflected in the meta-analyses. Only two (7%) reported RCT funding sources and none reported RCT author-industry ties. The authors concluded “without acknowledgement of COI due to industry funding or author industry financial ties from RCTs included in meta-analyses, readers’ understanding and appraisal of the evidence from the meta-analysis may be compromised.”[17]

In 2003 researchers looked at the association between authors' published positions on the safety and efficacy in assisting with weight loss of olestra, a fat substitute manufactured by the Procter & Gamble (P&G), and their financial relationships with the food and beverage industry. They found that supportive authors were significantly more likely than critical or neutral authors to have financial relationships with P&G and all authors disclosing an affiliation with P&G were supportive. The authors of the study concluded: "Because authors' published opinions were associated with their financial relationships, obtaining noncommercial funding may be more essential to maintaining objectivity than disclosing personal financial interests."[18]

A 2005 study in the journal Nature[19] surveyed 3247 US researchers who were all publicly funded (by the National Institutes of Health). Out of the scientists questioned, 15.5% admitted to altering design, methodology or results of their studies due to pressure of an external funding source.

A theoretical model has been established whose simulations imply that peer review and over-competitive research funding foster mainstream opinion to monopoly.[20]

History[edit]

In the eighteenth and nineteenth centuries, as the pace of technological progress increased before and during the industrial revolution, most scientific and technological research was carried out by individual inventors using their own funds. A system of patents was developed to allow inventors a period of time (often twenty years) to commercialise their inventions and recoup a profit, although in practice many found this difficult. The talents of an inventor are not those of a businessman, and there are many examples of inventors (e.g. Charles Goodyear) making rather little money from their work whilst others were able to market it.[citation needed]

In the twentieth century, scientific and technological research became increasingly systematised, as corporations developed, and discovered that continuous investment in research and development could be a key element of success in a competitive strategy. It remained the case, however, that imitation by competitors - circumventing or simply flouting patents, especially those registered abroad - was often just as successful a strategy for companies focused on innovation in matters of organisation and production technique, or even in marketing. A classic example is that of Wilkinson Sword and Gillette in the disposable razor market, where the former has typically had the technological edge, and the latter the commercial one.[citation needed]

See also[edit]

References[edit]

  1. ^ Taylor, R.A., Socioeconomic impacts of heat transfer research, International Communications in Heat and Mass Transfer, Volume 39, Issue 10, December 2012, Pages 1467–1473, http://www.sciencedirect.com/science/article/pii/S0735193312002199
  2. ^ a b William J. Broad (2014-03-15). "Billionaires With Big Ideas Are Privatizing American Science". New York Times. Retrieved 30 Nov 2014. 
  3. ^ a b Giles, Jim (2012). "Finding philanthropy: Like it? Pay for it". Nature 481: 252–253. doi:10.1038/481252a. 
  4. ^ http://www.webguru.neu.edu/undergraduate-research/research-funding/possible-funding-sources
  5. ^ Jaruzelski, B.; V. Staack; B. Goehle (2014). Global Innovation 1000: Proven Paths to Innovation Success (Technical report). Strategy&. 77. 
  6. ^ http://www.sfgate.com/news/article/New-Palo-Alto-lab-for-life-science-startups-5717097.php
  7. ^ http://onstartups.com/tabid/3339/bid/76387/7-Lessons-On-Startup-Funding-From-a-Research-Scientist.aspx
  8. ^ Corbyn, Zoë (2009-07-02). "'Sandpits' bring out worst in 'infantilised' researchers". Times Higher Education (TSL Education). Sandpits, which were devised by the Engineering and Physical Sciences Research Council, typically involve about 30 selected researchers from different areas who are brought together for several days of intensive discussions about a particular topic. [...] The wheels of such events are oiled with the promise of up to £1 million in funding, which is dished out at the end through a group peer-review process. 
  9. ^ Gonzales, Evelina Garza, "External Funding and Tenure at Texas State University-San Marcos" (2009). Texas State University. Applied Research Projects. Paper 315. http://ecommons.txstate.edu/arp/315
  10. ^ Robert A. Killoren, Jr., Associate Vice President for Research, Office of Sponsored Programs, Penn State U, Fall 2005. From Lowry, Peggy (2006) "Assessing the Sponsored Research Office". SPONSORED RESEARCH ADMINISTRATION: A Guide to Effective Strategies and Recommended Practices
  11. ^ http://undsci.berkeley.edu/article/0_0_0/who_pays
  12. ^ Lenard I Lesser, Cara B Ebbeling, Merrill Goozner, David Wypij, David S Ludwig (January 9, 2007). "Relationship between Funding Source and Conclusion among Nutrition-Related Scientific Articles". PLOS Medicine. PLOS. doi:10.1371/journal.pmed.0040005. Retrieved 24 March 2014. 
  13. ^ Marion Nestle (October 2001). "Food company sponsorship of nutrition research and professional activities: a conflict of interest?". Public Health Nutrition. Cambridge University Press. doi:10.1079/PHN2001253. Retrieved 24 March 2014. 
  14. ^ "Sponsorship, authorship and accountability". CMAJ 165 (6): 786–8. September 2001. PMC 81460. PMID 11584570. 
  15. ^ R J P M Scholten, M Clarke, J Hetherington (Aug 2005). "The Cochrane Collaboration". Eur J Clin Nutr. Suppl 1 59 (S1): S147–S149. doi:10.1038/sj.ejcn.1602188. PMID 16052183. Retrieved 31 January 2012. 
  16. ^ The Cochrane Collaboration
  17. ^ "How Well Do Meta-Analyses Disclose Conflicts of Interests in Underlying Research Studies". The Cochrane Collaboration website. Cochrane Collaboration. 2011-06-06. Retrieved 24 March 2014. 
  18. ^ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447808/?tool=pubmed
  19. ^ Martinson, BC; Anderson, MS; De Vries, R (2005). "Scientists behaving badly". Nature 435 (7043): 737–8. doi:10.1038/435737a. PMID 15944677. 
  20. ^ H. Fang. "Peer review and over-competitive research funding fostering mainstream opinion to monopoly", Scientometrics, 87(2), pp. 293-301 (2011).

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