Furanolactone

The chemical structure of salvinorin A

A furanolactone is a heterocyclic chemical compound that contains both a lactone and a furan ring structure.

Examples include:

• The Salvinorins, including the hallucinogenic compound salvinorin A
• Columbin, a potential chemopreventive compound
• Limonoids such as limonin, nomilin, and nomilinic acid

References

1. Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Dersch CM, Rothman RB, Prisinzano TE. (2006). Synthetic studies of neoclerodane diterpenes from Salvia divinorum: selective modification of the furan ring. Bioorg Med Chem Lett 16(12):3170-4.
2. Kohno H, Maeda M, Tanino M, Tsukio Y, Ueda N, Wada K, Sugie S, Mori H, Tanaka T. (2002). A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis. Cancer Lett 183(2):131-9.
3. Swaminathan K, Sinha UC, Ramakumar S, Bhatt RK, Sabata BK. (1989). Structure of columbin, a diterpenoid furanolactone from Tinospora cordifolia Miers. Acta Crystallogr C 45 ( Pt 2):300-3.