Boil

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This article is about the contagious skin disease. For the change in state from liquid to gas, see Boiling. For other uses, see Boil (disambiguation).
Boils
Classification and external resources
Furoncle.jpg
Furuncle
ICD-10 L02
ICD-9 680.9
DiseasesDB 29434
MedlinePlus 001474 000825
MeSH D005667

A boil, also called a furuncle, is a deep folliculitis, infection of the hair follicle. It is most commonly caused by infection by the bacterium Staphylococcus aureus, resulting in a painful swollen area on the skin caused by an accumulation of pus and dead tissue.[1] Boils which are expanded are basically pus-filled nodules.[2][verification needed] Individual boils clustered together are called carbuncles.[3] Most human infections are caused by coagulase-positive S. aureus strains, notable for the bacteria's ability to produce coagulase, an enzyme that can clot blood. Almost any organ system can be infected by S. aureus.

Signs and issues[edit]

Boils are bumpy, red, pus-filled lumps around a hair follicle that are tender, warm, and very painful. They range from pea-sized to golf ball-sized. A yellow or white point at the centre of the lump can be seen when the boil is ready to drain or discharge pus. In a severe infection, an individual may experience fever, swollen lymph nodes, and fatigue. A recurring boil is called chronic furunculosis.[1][4][5][6] Skin infections tend to be recurrent in many patients and often spread to other family members. Systemic factors that lower resistance commonly are detectable, including: diabetes, obesity, and hematologic disorders.[7] Boils can be caused by other skin conditions that cause the person to scratch and damage the skin.

Boils may appear on the buttocks or near the anus, the back, the neck, the stomach, the chest, the arms or legs, or even in the ear canal.[8] Boils may also appear around the eye, where they are called styes.[9] A boil on the gum is called intraoral dental sinus, or more commonly, a gumboil.

Causes[edit]

Bacteria[edit]

Usually, the cause is bacteria such as staphylococci that are present on the skin. Bacterial colonisation begins in the hair follicles and can cause local cellulitis and inflammation.[1][5][6] Additionally, myiasis caused by the Tumbu fly in Africa usually presents with cutaneous furuncles.[10] Risk factors for furunculosis include bacterial carriage in the nostrils, diabetes mellitus, obesity, lymphoproliferative neoplasms, malnutrition, and use of immunosuppressive drugs.[11]

Family history[edit]

People with recurrent boils are as well more likely to have a positive family history, take antibiotics, and to have been hospitalised, anemic, or diabetic; they are also more likely to have associated skin diseases and multiple lesions.[12]

Other[edit]

Other causes include poor immune system function such as from HIV/AIDS, diabetes, malnutrition, or alcoholism.[13] Poor hygiene and obesity have also been linked.[13] It may occur following antibiotic use due to the development of resistance to the antibiotics used.[14] An associated skin disease favors recurrence. This may be attributed to the persistent colonization of abnormal skin with S. aureus strains, such as is the case in persons with atopic dermatitis.[14]

Complications[edit]

The most common complications of boils are scarring and infection or abscess of the skin, spinal cord, brain, kidneys, or other organs. Infections may also spread to the bloodstream (bacteremia) and become life-threatening.[5][6] S. aureus strains first infect the skin and its structures (for example, sebaceous glands, hair follicles) or invade damaged skin (cuts, abrasions). Sometimes the infections are relatively limited (such as a stye, boil, furuncle, or carbuncle), but other times they may spread to other skin areas (causing cellulitis, folliculitis, or impetigo). Unfortunately, these bacteria can reach the bloodstream (bacteremia) and end up in many different body sites, causing infections (wound infections, abscesses, osteomyelitis, endocarditis, pneumonia)[15] that may severely harm or kill the infected person. S. aureus strains also produce enzymes and exotoxins that likely cause or increase the severity of certain diseases. Such diseases include food poisoning, septic shock, toxic shock syndrome, and scalded skin syndrome.[16] Almost any organ system can be infected by S. aureus.

Treatment[edit]

A small boil may burst and drain on its own without any assistance, however, this is rare. Antibiotic therapy is advisable for large or recurrent boils or those that occur in sensitive areas (such as the groin, breasts, armpits, around or in the nostrils or in the ear).[1][4][5][6] Most doctors that aren't specialists tend to treat boils with antibiotics, a less ideal but more common treatment, however this method should not be used for longer than one month, and at least two months (preferably longer) in between use or else it will lose its effectiveness.[17] More severe boils should be treated with Intralesional steroid injections.[18] If the patient has ongoing (more than two years) boils, then removal by plastic surgery is the best treatment, as these surgeons have a better understanding of the healing process of skin-especially on the outermost layers.

Furuncles at risk of leading to serious complications should be incised and drained, if antibiotics or steroid injections are not effective. These include furuncles that are unusually large, last longer than two weeks, or are located in the middle of the face or near the spine.[1][6] Fever and chills are signs of sepsis that require immediate treatment.[19]

Staphylococcus aureus has the ability to acquire antimicrobial resistance easily, making treatment difficult. Knowledge of the antimicrobial resistance of S. aureus is important in the selection of antimicrobials for treatment.[20]

See also[edit]

References[edit]

  1. ^ a b c d e MedlinePlus Encyclopedia Furuncle
  2. ^ "Causes and Cures of Skin". Healthguidance.org. Retrieved 26 July 2014. 
  3. ^ MedlinePlus Encyclopedia Carbuncle
  4. ^ a b Blume JE, Levine EG, Heymann WR (2003). "Bacterial diseases". In Bolognia JL, Jorizzo JL, Rapini RP. Dermatology. Mosby. p. 1126. ISBN 0-323-02409-2. 
  5. ^ a b c d Habif, TP (2004). "Furuncles and carbuncles". Clinical Dermatology: A Color Guide to Diagnosis and Therapy (4th ed.). Philadelphia PA: Mosby. 
  6. ^ a b c d e Wolf K, et al. (2005). "Section 22. Bacterial infections involving the skin". Fitzpatrick's Color Atlas & Synopsis of Clinical Dermatology (5th ed.). McGraw-Hill. 
  7. ^ Steele RW, Laner SA, Graves MH (February 1980). "Recurrent staphylococcal infection in families". Arch Dermatol 116 (2): 189–90. doi:10.1001/archderm.116.2.189. PMID 7356349. 
  8. ^ "Boils, Carbuncles and Furunculosis". Patient.co.uk. Retrieved 26 July 2014. 
  9. ^ "Boils, Kidshealth". http://www.kidshealth.org.nz. Retrieved 26 July 2014. 
  10. ^ Tamir J, Haik J, Schwartz E (2003). "Myiasis with Lund's fly (Cordylobia rodhaini) in travellers". J Travel Med 10 (5): 293–5. doi:10.2310/7060.2003.2732. PMID 14531984. 
  11. ^ Scheinfeld NS (2007). "Furunculosis". Consultant 47 (2). 
  12. ^ El-Gilany AH, Fathy H (January 2009). "Risk factors of recurrent furunculosis". Dermatol Online J 15 (1): 16. PMID 19281721. 
  13. ^ a b Demos, M; McLeod, MP; Nouri, K (Oct 2012). "Recurrent furunculosis: a review of the literature.". The British journal of dermatology 167 (4): 725–32. doi:10.1111/j.1365-2133.2012.11151.x. PMID 22803835. 
  14. ^ a b Laube S, Farrell M (2002). "Bacterial skin infection in the elderly: diagnosis and treatment". Drugs and Aging 19 (5): 331–42. doi:10.2165/00002512-200219050-00002. PMID 12093320. 
  15. ^ Lina G, Piémont Y, Godail-Gamot F, Bes M, Peter MO, Gauduchon V, Vandenesch F, Etienne J (November 1999). "Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia". Clin Infect Dis 29 (5): 1128–32. doi:10.1086/313461. PMID 10524952. 
  16. ^ http://www.emedicinehealth.com/staphylococcus/page4_em.htm
  17. ^ Mayo Clinic
  18. ^ [1]
  19. ^ ref=http://www.mayoclinic.com/health/boils-and-carbuncles/DS00466/DSECTION=complications
  20. ^ Nagaraju U, Bhat G, Kuruvila M, Pai GS, Babu RP (2004). "Methicillin-resistant staphylococcus aureus in community-acquired pyoderma". Int J Dermatol 43 (6): 412–4. doi:10.1111/j.1365-4632.2004.02138.x. PMID 15186220. 

External links[edit]