Fusafungine

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Fusafungine
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Identifiers
CAS number 1393-87-9 YesY
ATC code R02AB03
UNII 65DD690W0C YesY
KEGG D08002 N
Synonyms Fusafungin
Chemical data
Formula C29H51N2O8 
Mol. mass 555.72 g/mol[1]
 N (what is this?)  (verify)

Fusafungine (INN), also known as fusafungin, is an active agent used in antibiotics for treatment of nasal and throat infection. It also possesses anti-inflammatory properties. Fusafungine is a mixture of enniatin cyclohexadepsipeptides made up of alternating D-α-hydroxyvaleric acid and L-N-methylamino acid residues,[2] produced by the ascomycete Fusarium lateritium, and marketed by Servier under the trade names Locabiotal, Bioparox, and Locabiosol.

According to a pooled analysis study done in the UK for the efficacy of fusafungine in rhinopharingitis, it was found that the proportion of patients who showed an improvement in symptoms from Day 0 to Day 4 of infection was 61.5% with fusafungine vs. 46.8% when compared to a placebo. [3]

References[edit]

  1. ^ Fusafungine at MeSH
  2. ^ Daniel Levy, Aline Bluzat, Michel Seigneuret and Jean-Louis Rigaud (1995). "Alkali cation transport through liposomes by the antimicrobial fusafungine and its constitutive enniatins". Biochemical Pharmacology 50 (12 22): 2105–2107. doi:10.1016/0006-2952(95)02045-4. PMID 8849339. 
  3. ^ http://www.ncbi.nlm.nih.gov/pubmed/15626253