Fyn-related kinase

Fyn-related kinase
Identifiers
Symbols	FRK; GTK; PTK5; RAK
External IDs	OMIM: 606573 MGI: 103265 HomoloGene: 48065 ChEMBL: 4223 GeneCards: FRK Gene
EC number	2.7.10.2
Gene Ontology Molecular function • non-membrane spanning protein tyrosine kinase activity • protein binding • ATP binding Cellular component • intracellular • nucleus • cytoplasm • plasma membrane Biological process • protein phosphorylation • negative regulation of cell proliferation • cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2444	14302
Ensembl	ENSG00000111816	ENSMUSG00000019779
UniProt	P42685	Q922K9
RefSeq (mRNA)	NM_002031	NM_001159544
RefSeq (protein)	NP_002022	NP_001153016
Location (UCSC)	Chr 6: 116.26 – 116.38 Mb	Chr 10: 34.48 – 34.61 Mb
PubMed search	[1]	[2]

Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.

Interactions

FRK has been shown to interact with retinoblastoma protein.

Further reading

• Serfas MS, Tyner AL (2003). "Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.". Oncol. Res. 13 (6-10): 409–19. PMID 12725532. 
• Craven RJ, Cance WG, Liu ET (1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb.". Cancer Res. 55 (18): 3969–72. PMID 7664264. 
• Cance WG, Craven RJ, Bergman M, et al. (1995). "Rak, a novel nuclear tyrosine kinase expressed in epithelial cells.". Cell Growth Differ. 5 (12): 1347–55. PMID 7696183. 
• Cance WG, Craven RJ, Weiner TM, Liu ET (1993). "Novel protein kinases expressed in human breast cancer.". Int. J. Cancer 54 (4): 571–7. doi:10.1002/ijc.2910540409. PMID 8099900. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Meyer T, Xu L, Chang J, et al. (2003). "Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase.". Int. J. Cancer 104 (2): 139–46. doi:10.1002/ijc.10925. PMID 12569567. 
• Watanabe T, Ohnuma T, Shibata N, et al. (2004). "No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease.". Neurosci. Lett. 360 (1-2): 109–11. doi:10.1016/j.neulet.2004.02.046. PMID 15082191. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.