Gábor Vajta

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Gábor Vajta
Vajta1.png
Born (1952-08-25) 25 August 1952 (age 62)
Vác, Hungary
Residence Cairns, Queensland, Australia
Nationality Australian, Hungarian
Fields Embryologist
Known for HMC (Handmade Cloning)
Website
www.gaborvajta.com

Gábor Vajta, MD, PhD, DSc (born 25 August 1952) is an Australian-Hungarian embryologist, Professorial Research Fellow at the Central Queensland University and Honorary Professor of the Beijing Institute of Genomics. After an early career in human pathology he turned to embryology in 1989 and since then has developed several patents relating to embryology, most notably the method of Handmade Cloning (HMC).[1] HMC is a radical technical modification of Somatic cell nuclear transfer of the original mammalian nuclear transfer technology established by Willadsen and applied for somatic cells by Wilmut and Campbell.

Research[edit]

Vajta’s achievements in embryology, either personal or by supervised students, include the establishment of a new incubation method for embryo production (Submarine Incubation System, SIS[2]), establishment of a new vitrification method (Open Pulled Straw, OPS[3]), establishment of a new method for culturing embryos (Well of Wells, WOW[4]) however he is most recognised for the development of Handmade Cloning (HMC).[5]

Handmade Cloning[edit]

Handmade cloning (HMC) is a simplified form of Somatic cell nuclear transfer. The technique does not require micromanipulators only a simple stereomicroscope and an inexpensive fusion machine. All work is done by hand, with simple handheld tools (blade and micropipette).The first cloned animals in Africa[6][7] and Scandinavia[8] were both produced by HMC. Transgenic pigs as models for various human diseases were produced with putative genes responsible for Parkinson's and Alzheimer's disease, Psoriasis, Arteriosclerosis and Diabetes mellitus. The technology promises a new possibility for automation of the somatic cell nuclear transfer procedure. The birth of the first transgenic piglets containing the Alzheimer gene (29 October 2006)[9] was rewarded as the Most important Scientific Achievement in Denmark in 2007.[10]

References[edit]

  1. ^ "Cell Nuclear Transfer" patent no. US20090119787
  2. ^ Vajta, G.; Holm, P.; Greve, T.; Callesen, H. (1997). "The submarine incubation system, a new tool for in vitro embryo culture: A technique report". Theriogenology 48 (8): 1379. doi:10.1016/S0093-691X(97)00379-8.  edit
  3. ^ Vajta, G.; Holm, P.; Kuwayama, M.; Booth, P. J.; Jacobsen, H.; Greve, T.; Callesen, H. (1998). "Open pulled straw (OPS) vitrification: A new way to reduce cryoinjuries of bovine ova and embryos". Molecular Reproduction and Development 51 (1): 53–8. doi:10.1002/(SICI)1098-2795(199809)51:1<53::AID-MRD6>3.0.CO;2-V. PMID 9712317.  edit
  4. ^ Vajta, G.; Peura, T. T.; Holm, P.; p�Ldi, A.; Greve, T.; Trounson, A. O.; Callesen, H. (2000). "New method for culture of zona-included or zona-free embryos: The Well of the Well (WOW) system". Molecular Reproduction and Development 55 (3): 256–64. doi:10.1002/(SICI)1098-2795(200003)55:3<256::AID-MRD3>3.0.CO;2-7. PMID 10657044.  edit
  5. ^ Vajta, G. B.; Lewis, I. M.; Hyttel, P.; Thouas, G. A.; Trounson, A. O. (2001). "Somatic Cell Cloning without Micromanipulators". Cloning 3 (2): 89–95. doi:10.1089/15204550152475590. PMID 11900643.  edit
  6. ^ "Futi on Embryo Plus"
  7. ^ "Futi on BBC”
  8. ^ "Danish piglets”
  9. ^ Kragh, P. M.; Nielsen, A. L.; Li, J.; Du, Y.; Lin, L.; Schmidt, M.; Bøgh, I. B. C.; Holm, I. E.; Jakobsen, J. E.; Johansen, M. G.; Purup, S.; Bolund, L.; Vajta, G. B.; Jørgensen, A. L. (2009). "Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw". Transgenic Research 18 (4): 545–558. doi:10.1007/s11248-009-9245-4. PMID 19184503.  edit
  10. ^ "Ingeniøren Magazine" in Danish language

External links[edit]