G-130

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This article is about the stimulant drug. For the glycoprotein, see Gp130.
G-130
G-130 structure.png
Systematic (IUPAC) name
2-phenyl-5,5-dimethylmorpholine
Clinical data
Legal status
?
Identifiers
CAS number 42013-48-9 YesY
ATC code ?
PubChem CID 97711
ChemSpider 88190
Chemical data
Formula C12H17NO 
Mol. mass 191.269 g/mol
 YesY (what is this?)  (verify)

G-130 (GP-130, 2-Phenyl-5,5-dimethyltetrahydro-1,4-oxazine)[1] is a drug with stimulant and anorectic effects, related to phenmetrazine.[2][3][4]

Structural analogs[edit]

Compounds related to G 130 and radafaxine were synthesized that behave as combined inhibitors of monoamine uptake and nAChRs.[5]

See also[edit]

References[edit]

  1. ^ GB 1336732  - Diethanolamine Derivatives.
  2. ^ Fanelli O (June 1973). "Pharmacological and toxicological study of a new psychotropic stimulant: the 2-phenyl-5-dimethyl-tetrahydro-1,4-oxazine, in comparison with d,l-amphetamine, phenmetrazine and pemoline-Mg". Arzneimittel-Forschung 23 (6): 810–6. PMID 4740767. 
  3. ^ Fanelli O, Mazzoncini V, Ferri S (October 1974). "Toxicological and teratological study of 2-phenyl-5,5-dimethyl-tetrahydro-1,4-oxazine hydrochloride (G 130), a psychostimulant drug". Arzneimittel-Forschung 24 (10): 1627–32. PMID 4479774. 
  4. ^ Fanelli O, Mazzoncini V, Trallori L (December 1974). "Antagonism of psychostimulant 2-phenyl-5,5-dimethyl-tetrahydro-1,4-oxazine hydrochloride (G 130) to central nervous system depressing drugs. Monoamine oxidase inhibitory activity and norepinephrine and serotonin induced changes. Comparison with dL-amphetamine". Arzneimittel-Forschung 24 (12): 2025–9. PMID 4480283. 
  5. ^ Carroll, F. I.; Muresan, A. Z.; Blough, B. E.; Navarro, H. N. A.; Mascarella, S. W.; Eaton, J. B.; Huang, X.; Damaj, M. I.; Lukas, R. J. (2011). "Synthesis of 2-(Substituted Phenyl)-3,5,5-trimethylmorpholine Analogues and Their Effects on Monoamine Uptake, Nicotinic Acetylcholine Receptor Function, and Behavioral Effects of Nicotine". Journal of Medicinal Chemistry 54 (5): 1441–1448. doi:10.1021/jm1014555. PMC 3048909. PMID 21319801.  edit