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GTPase activating protein (SH3 domain) binding protein 2
Symbol G3BP2
External IDs MGI2442040 HomoloGene137244 GeneCards: G3BP2 Gene
RNA expression pattern
PBB GE G3BP2 208841 s at tn.png
PBB GE G3BP2 206383 s at tn.png
PBB GE G3BP2 208840 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9908 23881
Ensembl ENSG00000138757 ENSMUSG00000029405
UniProt Q9UN86 P97379
RefSeq (mRNA) NM_012297 NM_001080794
RefSeq (protein) NP_036429 NP_001074263
Location (UCSC) Chr 4:
76.57 – 76.65 Mb
Chr 5:
92.05 – 92.08 Mb
PubMed search [1] [2]

Ras GTPase-activating protein-binding protein 2 is an enzyme that in humans is encoded by the G3BP2 gene.[1][2][3]


G3BP2 has been shown to interact with IκBα.[4]


  1. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  2. ^ Kennedy D, Wood SA, Ramsdale T, Tam PP, Steiner KA, Mattick JS (June 1998). "Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif". Biomed Pept Proteins Nucleic Acids 2 (3): 93–9. PMID 9575347. 
  3. ^ "Entrez Gene: G3BP2 GTPase activating protein (SH3 domain) binding protein 2". 
  4. ^ Prigent, M; Barlat I; Langen H; Dargemont C (November 2000). "IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2". J. Biol. Chem. (UNITED STATES) 275 (46): 36441–9. doi:10.1074/jbc.M004751200. ISSN 0021-9258. PMID 10969074. 

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