GAB1

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GRB2-associated binding protein 1
Identifiers
Symbol GAB1
External IDs OMIM604439 MGI108088 HomoloGene1542 GeneCards: GAB1 Gene
RNA expression pattern
PBB GE GAB1 207112 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2549 14388
Ensembl ENSG00000109458 ENSMUSG00000031714
UniProt Q13480 Q9QYY0
RefSeq (mRNA) NM_002039 NM_001301298
RefSeq (protein) NP_002030 NP_001288227
Location (UCSC) Chr 4:
144.26 – 144.4 Mb
Chr 8:
80.76 – 80.88 Mb
PubMed search [1] [2]

GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene.[1]

Function[edit]

The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. The encoded protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.[2]

Interactions[edit]

GAB1 has been shown to interact with:

The expression of GAB1 was shown to be regulated by non-coding RNA (miRNA) termed miR-150.[11]

References[edit]

  1. ^ a b c d Holgado-Madruga M, Emlet DR, Moscatello DK, Godwin AK, Wong AJ (April 1996). "A Grb2-associated docking protein in EGF- and insulin-receptor signalling". Nature 379 (6565): 560–4. doi:10.1038/379560a0. PMID 8596638. 
  2. ^ "Entrez Gene: GAB1 GRB2-associated binding protein 1". 
  3. ^ Sakkab D, Lewitzky M, Posern G, Schaeper U, Sachs M, Birchmeier W et al. (April 2000). "Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL". J. Biol. Chem. 275 (15): 10772–8. doi:10.1074/jbc.275.15.10772. PMID 10753869. 
  4. ^ Oneyama C, Nakano H, Sharma SV (March 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug". Oncogene 21 (13): 2037–50. doi:10.1038/sj.onc.1205271. PMID 11960376. 
  5. ^ Lewitzky M, Kardinal C, Gehring NH, Schmidt EK, Konkol B, Eulitz M et al. (March 2001). "The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif". Oncogene 20 (9): 1052–62. doi:10.1038/sj.onc.1204202. PMID 11314042. 
  6. ^ Che W, Lerner-Marmarosh N, Huang Q, Osawa M, Ohta S, Yoshizumi M et al. (June 2002). "Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression". Circ. Res. 90 (11): 1222–30. doi:10.1161/01.res.0000021127.83364.7d. PMID 12065326. 
  7. ^ Bertagnolo V, Marchisio M, Volinia S, Caramelli E, Capitani S (December 1998). "Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-gamma1 and phosphoinositide 3-kinase during granulocytic differentiation of HL-60 cells". FEBS Lett. 441 (3): 480–4. doi:10.1016/s0014-5793(98)01593-2. PMID 9891995. 
  8. ^ a b Rocchi S, Tartare-Deckert S, Murdaca J, Holgado-Madruga M, Wong AJ, Van Obberghen E (July 1998). "Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules". Mol. Endocrinol. 12 (7): 914–23. doi:10.1210/mend.12.7.0141. PMID 9658397. 
  9. ^ Ueno E, Haruta T, Uno T, Usui I, Iwata M, Takano A et al. (July 2001). "Potential role of Gab1 and phospholipase C-gamma in osmotic shock-induced glucose uptake in 3T3-L1 adipocytes". Horm. Metab. Res. 33 (7): 402–6. doi:10.1055/s-2001-16227. PMID 11507676. 
  10. ^ Saito Y, Hojo Y, Tanimoto T, Abe J, Berk BC (June 2002). "Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor". J. Biol. Chem. 277 (26): 23216–22. doi:10.1074/jbc.M200605200. PMID 11940581. 
  11. ^ Mraz M, Chen L, Rassenti LZ, Ghia EM, Li H, Jepsen K et al. (2014). "MiR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1". Blood 124 (1): 84–95. doi:10.1182/blood-2013-09-527234. PMID 24787006. 

Further reading[edit]