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GABA(A) receptor-associated protein
Protein GABARAP PDB 1gnu.png
PDB rendering based on 1gnu.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM605125 MGI1861742 HomoloGene134119 GeneCards: GABARAP Gene
RNA expression pattern
PBB GE GABARAP 200645 at tn.png
More reference expression data
Species Human Mouse
Entrez 11337 56486
Ensembl ENSG00000170296 ENSMUSG00000018567
UniProt O95166 Q9DCD6
RefSeq (mRNA) NM_007278 NM_019749
RefSeq (protein) NP_009209 NP_062723
Location (UCSC) Chr 17:
7.14 – 7.15 Mb
Chr 11:
69.99 – 69.99 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor-associated protein is a protein that in humans is encoded by the GABARAP gene.[1]


Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.[2]

A study has screened 2000 participants representing more than 600 families of smokers and examined different genes showing linkage to nicotine addiction. Some of these showing linkage are the GABA-B receptor subunit 2 (GABAB2) gene on chromosome 9, and the GABA-A receptor-associated protein (GABARAP) gene on chromosome 17.[3]


GABARAP has been shown to interact with TFRC,[4] ULK1[5][6] and GABRG2.[1][7][8]


  1. ^ a b Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW (Jan 1999). "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton". Nature 397 (6714): 69–72. doi:10.1038/16264. PMID 9892355. 
  2. ^ "Entrez Gene: GABARAP GABA(A) receptor-associated protein". 
  3. ^ "Nicotine Addiction Might Be Controlled By Influencing Brain Mechanisms". 2007-12-10. 
  4. ^ Green F, O'Hare T, Blackwell A, Enns CA (May 2002). "Association of human transferrin receptor with GABARAP". FEBS Letters 518 (1-3): 101–106. doi:10.1016/S0014-5793(02)02655-8. PMID 11997026. 
  5. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  6. ^ Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y et al. (Dec 2000). "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation". Brain Research. Molecular Brain Research 85 (1-2): 1–12. doi:10.1016/S0169-328X(00)00218-7. PMID 11146101. 
  7. ^ Nymann-Andersen J, Wang H, Chen L, Kittler JT, Moss SJ, Olsen RW (Mar 2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors". Journal of Neurochemistry 80 (5): 815–823. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245. 
  8. ^ Coyle JE, Qamar S, Rajashankar KR, Nikolov DB (Jan 2002). "Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding". Neuron 33 (1): 63–74. doi:10.1016/S0896-6273(01)00558-X. PMID 11779480. 

Further reading[edit]