GABRA2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Gamma-aminobutyric acid (GABA) A receptor, alpha 2
Identifiers
Symbol GABRA2
External IDs OMIM137140 MGI95614 HomoloGene20217 IUPHAR: α2 ChEMBL: 4956 GeneCards: GABRA2 Gene
RNA expression pattern
PBB GE GABRA2 207014 at tn.png
PBB GE GABRA2 216039 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2555 14395
Ensembl ENSG00000151834 ENSMUSG00000000560
UniProt P47869 P26048
RefSeq (mRNA) NM_000807 NM_008066
RefSeq (protein) NP_000798 NP_032092
Location (UCSC) Chr 4:
46.25 – 46.48 Mb
Chr 5:
70.96 – 71.1 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit alpha-2 is a protein that in humans is encoded by the GABRA2 gene.[1]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.[1]

See also[edit]

References[edit]

Further reading[edit]

External links[edit]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.