GABRG1

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Gamma-aminobutyric acid (GABA) A receptor, gamma 1
Identifiers
Symbols GABRG1 ; DKFZp686H2042; MGC33838
External IDs OMIM137166 MGI103156 HomoloGene22570 IUPHAR: γ1 ChEMBL: 4044 GeneCards: GABRG1 Gene
Orthologs
Species Human Mouse
Entrez 2565 14405
Ensembl ENSG00000163285 ENSMUSG00000001260
UniProt Q8N1C3 Q9R0Y8
RefSeq (mRNA) NM_173536 NM_010252
RefSeq (protein) NP_775807 NP_034382
Location (UCSC) Chr 4:
46.04 – 46.13 Mb
Chr 5:
70.75 – 70.84 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit gamma-1 is a protein that in humans is encoded by the GABRG1 gene.[1] The protein encoded by this gene is a subunit of the GABAA receptor.[2]

Variants of this gene may be associated with alcohol dependence.[3]

References[edit]

  1. ^ Wilcox AS, Warrington JA, Gardiner K, Berger R, Whiting P, Altherr MR, Wasmuth JJ, Patterson D, Sikela JM (July 1992). "Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5857–61. doi:10.1073/pnas.89.13.5857. PMC 49396. PMID 1321425. 
  2. ^ Hevers W, Lüddens H (August 1998). "The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes". Mol. Neurobiol. 18 (1): 35–86. doi:10.1007/BF02741459. PMID 9824848. 
  3. ^ Ittiwut C, Listman J, Mutirangura A, Malison R, Covault J, Kranzler HR, Sughondhabirom A, Thavichachart N, Gelernter J (January 2008). "Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4". Genomics 91 (1): 61–9. doi:10.1016/j.ygeno.2007.08.007. PMC 2709929. PMID 17976953. 

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