GABRG2

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Gamma-aminobutyric acid (GABA) A receptor, gamma 2
Identifiers
Symbols GABRG2 ; CAE2; ECA2; GEFSP3
External IDs OMIM137164 MGI95623 HomoloGene22443 IUPHAR: γ2 ChEMBL: 1788 GeneCards: GABRG2 Gene
RNA expression pattern
PBB GE GABRG2 206849 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2566 14406
Ensembl ENSG00000113327 ENSMUSG00000020436
UniProt P18507 P22723
RefSeq (mRNA) NM_000816 NM_008073
RefSeq (protein) NP_000807 NP_032099
Location (UCSC) Chr 5:
161.49 – 161.58 Mb
Chr 11:
41.91 – 42 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit gamma-2 is a protein that in humans is encoded by the GABRG2 gene.

Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA(A) subunits. This gene encodes the gamma 2 subunit of GABA(A) receptor. Mutations in this gene have been associated with epilepsy and febrile seizures. Alternative splicing of this gene results in transcript variants encoding different isoforms.[1]

Interactions[edit]

GABRG2 has been shown to interact with GABARAP[2][3][4] and Dopamine receptor D5.[5]

See also[edit]

References[edit]

  1. ^ "Entrez Gene: GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2". 
  2. ^ Nymann-Andersen, Jesper; Wang Hongbing; Chen Li; Kittler Josef T; Moss Stephen J; Olsen Richard W (March 2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors". J. Neurochem. (England) 80 (5): 815–23. doi:10.1046/j.0022-3042.2002.00762.x. ISSN 0022-3042. PMID 11948245. 
  3. ^ Coyle, Joseph E; Qamar Seema; Rajashankar Kanagalaghatta R; Nikolov Dimitar B (January 2002). "Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding". Neuron (United States) 33 (1): 63–74. doi:10.1016/S0896-6273(01)00558-X. ISSN 0896-6273. PMID 11779472. 
  4. ^ Wang, H; Bedford F K; Brandon N J; Moss S J; Olsen R W (January 1999). "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton". Nature (ENGLAND) 397 (6714): 69–72. doi:10.1038/16264. ISSN 0028-0836. PMID 9892355. 
  5. ^ Liu, F; Wan Q; Pristupa Z B; Yu X M; Wang Y T; Niznik H B (January 2000). "Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors". Nature (ENGLAND) 403 (6767): 274–80. doi:10.1038/35002014. ISSN 0028-0836. PMID 10659839. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.