GABRG3

Gamma-aminobutyric acid (GABA) A receptor, gamma 3
Identifiers
Symbols	GABRG3;
External IDs	OMIM: 600233 MGI: 95624 HomoloGene: 22444 IUPHAR: γ3 GeneCards: GABRG3 Gene
Gene Ontology Molecular function • GABA-A receptor activity • ion channel activity • extracellular ligand-gated ion channel activity • chloride channel activity Cellular component • plasma membrane • integral to membrane • cell junction • chloride channel complex • synapse • postsynaptic membrane Biological process • gamma-aminobutyric acid signaling pathway • synaptic transmission • synaptic transmission • ion transmembrane transport • response to drug • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2567	14407
Ensembl	ENSG00000182256	ENSMUSG00000055026
UniProt	Q99928	P27681
RefSeq (mRNA)	NM_033223	NM_008074.2
RefSeq (protein)	NP_150092	NP_032100.2
Location (UCSC)	Chr 15: 27.22 – 27.78 Mb	Chr 7: 63.97 – 64.64 Mb
PubMed search	[1]	[2]

GABA_A receptor-γ3, also known as GABRG3, is a protein which in humans is encoded by the GABRG3 gene.

Function

GABRG3 is a subunit of the GABA_A receptor for the neurotransmitter gamma-Aminobutyric acid (GABA).

Association with alcoholism

Genetic markers near the GABRG3 gene are statistically linked to alcoholism.

See also

• GABAA receptor

Further reading

• Greger V, Knoll JH, Woolf E, et al. (1995). "The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3) is tightly linked to the alpha 5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation.". Genomics 26 (2): 258–64. doi:10.1016/0888-7543(95)80209-5. PMID 7601451. 
• Tögel M, Mossier B, Fuchs K, Sieghart W (1994). "gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties.". J. Biol. Chem. 269 (17): 12993–8. PMID 8175718. 
• Hadingham KL, Wafford KA, Thompson SA, et al. (1996). "Expression and pharmacology of human GABAA receptors containing gamma 3 subunits.". Eur. J. Pharmacol. 291 (3): 301–9. doi:10.1016/0922-4106(95)90070-5. PMID 8719414. 
• Poulsen CF, Christjansen KN, Hastrup S, Hartvig L (2000). "Identification and cloning of a gamma 3 subunit splice variant of the human GABA(A) receptor.". Brain Res. Mol. Brain Res. 78 (1-2): 201–3. doi:10.1016/S0169-328X(00)00085-1. PMID 10891602. 
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. 
• Nymann-Andersen J, Wang H, Chen L, et al. (2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors.". J. Neurochem. 80 (5): 815–23. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Dick DM, Edenberg HJ, Xuei X, et al. (2004). "Association of GABRG3 with alcohol dependence.". Alcohol. Clin. Exp. Res. 28 (1): 4–9. doi:10.1097/01.ALC.0000108645.54345.98. PMID 14745296. 
• Gole L, Crolla JA, Thomas SN, et al. (2004). "Characterization of breakpoints in the GABRG3 and TSPY genes in a family with a t(Y;15)(p11.2;q12).". Am. J. Med. Genet. A 125 (2): 177–80. doi:10.1002/ajmg.a.20482. PMID 14981720. 

External links

• MeSH GABRG3+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.