GABRP

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Gamma-aminobutyric acid (GABA) A receptor, pi
Identifiers
Symbols GABRP ; MGC126386; MGC126387
External IDs OMIM602729 MGI2387597 HomoloGene22798 IUPHAR: π ChEMBL: 3506 GeneCards: GABRP Gene
RNA expression pattern
PBB GE GABRP 205044 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2568 216643
Ensembl ENSG00000094755 ENSMUSG00000020159
UniProt O00591 Q8QZW7
RefSeq (mRNA) NM_001291985 NM_146017
RefSeq (protein) NP_001278914 NP_666129
Location (UCSC) Chr 5:
170.19 – 170.24 Mb
Chr 11:
33.55 – 33.58 Mb
PubMed search [1] [2]

Gamma-aminobutyric acid receptor subunit pi is a protein that in humans is encoded by the GABRP gene.[1][2]

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.[2]

See also[edit]

References[edit]

  1. ^ Hedblom E, Kirkness EF (Jul 1997). "A novel class of GABAA receptor subunit in tissues of the reproductive system". J Biol Chem 272 (24): 15346–50. doi:10.1074/jbc.272.24.15346. PMID 9182563. 
  2. ^ a b "Entrez Gene: GABRP gamma-aminobutyric acid (GABA) A receptor, pi". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.