GADD45G
From Wikipedia, the free encyclopedia
| Growth arrest and DNA-damage-inducible, gamma | |||||||||||
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 Rendering based on PDB 2WAL. |
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| Identifiers | |||||||||||
| Symbols | GADD45G; CR6; DDIT2; GADD45gamma; GRP17 | ||||||||||
| External IDs | OMIM: 604949 MGI: 1346325 HomoloGene: 21334 GeneCards: GADD45G Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 10912 | 23882 | |||||||||
| Ensembl | ENSG00000130222 | ENSMUSG00000021453 | |||||||||
| UniProt | O95257 | Q99M58 | |||||||||
| RefSeq (mRNA) | NM_006705 | NM_011817.2 | |||||||||
| RefSeq (protein) | NP_006696 | NP_035947.2 | |||||||||
| Location (UCSC) | Chr 9: 92.22 – 92.22 Mb |
Chr 13: 51.94 – 51.94 Mb |
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| PubMed search | [1] | [2] | |||||||||
Growth arrest and DNA-damage-inducible protein GADD45 gamma is a protein that in humans is encoded by the GADD45G gene.[1][2][3]
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta.[3]
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[edit] Interactions
GADD45G has been shown to interact with MAP3K4,[1] PCNA,[4][5] GADD45GIP1[6] and P21.[4][5]
[edit] See also
[edit] References
- ^ a b Takekawa M, Saito H (Dec 1998). "A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK". Cell 95 (4): 521–30. doi:10.1016/S0092-8674(00)81619-0. PMID 9827804.
- ^ Suzuki M, Watanabe TK, Fujiwara T, Nakamura Yp6, Takahashi E, Tanigami A (Oct 1999). "Molecular cloning, expression, and mapping of a novel human cDNA, GRP17, highly homologous to human gadd45 and murine MyD118". J Hum Genet 44 (5): 300–3. doi:10.1007/s100380050164. PMID 10496071.
- ^ a b "Entrez Gene: GADD45G growth arrest and DNA-damage-inducible, gamma". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10912.
- ^ a b Azam, N; Vairapandi M, Zhang W, Hoffman B, Liebermann D A (Jan. 2001). "Interaction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth control". J. Biol. Chem. (United States) 276 (4): 2766–74. doi:10.1074/jbc.M005626200. ISSN 0021-9258. PMID 11022036.
- ^ a b Nakayama, K; Hara T, Hibi M, Hirano T, Miyajima A (Aug. 1999). "A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth". J. Biol. Chem. (UNITED STATES) 274 (35): 24766–72. doi:10.1074/jbc.274.35.24766. ISSN 0021-9258. PMID 10455148.
- ^ Chung, Hyo Kyun; Yi Yong-Weon, Jung Neon-Cheol, Kim Daegun, Suh Jae Mi, Kim Ho, Park Ki Cheol, Song Jung Hun, Kim Dong Wook, Hwang Eun Suk, Yoon Soo-Hyun, Bae Young-Seuk, Kim Jin Man, Bae Insoo, Shong Minho (Jul. 2003). "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle". J. Biol. Chem. (United States) 278 (30): 28079–88. doi:10.1074/jbc.M212835200. ISSN 0021-9258. PMID 12716909.
[edit] Further reading
- Beadling C, Johnson KW, Smith KA (1993). "Isolation of interleukin 2-induced immediate-early genes.". Proc. Natl. Acad. Sci. U.S.A. 90 (7): 2719–23. doi:10.1073/pnas.90.7.2719. PMC 46167. PMID 7681987. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=46167.
- Nakayama K, Hara T, Hibi M, et al. (1999). "A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth.". J. Biol. Chem. 274 (35): 24766–72. doi:10.1074/jbc.274.35.24766. PMID 10455148.
- Zhang W, Bae I, Krishnaraju K, et al. (1999). "CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control.". Oncogene 18 (35): 4899–907. doi:10.1038/sj.onc.1202885. PMID 10490824.
- Fan W, Richter G, Cereseto A, et al. (2000). "Cytokine response gene 6 induces p21 and regulates both cell growth and arrest.". Oncogene 18 (47): 6573–82. doi:10.1038/sj.onc.1203054. PMID 10597261.
- Gong R, Yu L, Zhang H, et al. (2000). "Assignment of human GADD45G to chromosome 9q22.1→q22.3 by radiation hybrid mapping.". Cytogenet. Cell Genet. 88 (1-2): 95–6. doi:10.1159/000015496. PMID 10773677.
- Yi YW, Kim D, Jung N, et al. (2000). "Gadd45 family proteins are coactivators of nuclear hormone receptors.". Biochem. Biophys. Res. Commun. 272 (1): 193–8. doi:10.1006/bbrc.2000.2760. PMID 10872826.
- Yang Q, Manicone A, Coursen JD, et al. (2001). "Identification of a functional domain in a GADD45-mediated G2/M checkpoint.". J. Biol. Chem. 275 (47): 36892–8. doi:10.1074/jbc.M005319200. PMID 10973963.
- Azam N, Vairapandi M, Zhang W, et al. (2001). "Interaction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth control.". J. Biol. Chem. 276 (4): 2766–74. doi:10.1074/jbc.M005626200. PMID 11022036.
- Wan Y, Wang Z, Shao Y, et al. (2001). "UV-induced expression of GADD45 is mediated by an oxidant sensitive pathway in cultured human keratinocytes and in human skin in vivo.". Int. J. Mol. Med. 6 (6): 683–8. PMID 11078829.
- Kovalsky O, Lung FD, Roller PP, Fornace AJ (2001). "Oligomerization of human Gadd45a protein.". J. Biol. Chem. 276 (42): 39330–9. doi:10.1074/jbc.M105115200. PMID 11498536.
- Zhang X, Sun H, Danila DC, et al. (2002). "Loss of expression of GADD45 gamma, a growth inhibitory gene, in human pituitary adenomas: implications for tumorigenesis.". J. Clin. Endocrinol. Metab. 87 (3): 1262–7. doi:10.1210/jc.87.3.1262. PMID 11889197.
- Vairapandi M, Balliet AG, Hoffman B, Liebermann DA (2002). "GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress.". J. Cell. Physiol. 192 (3): 327–38. doi:10.1002/jcp.10140. PMID 12124778.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Chung HK, Yi YW, Jung NC, et al. (2003). "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle.". J. Biol. Chem. 278 (30): 28079–88. doi:10.1074/jbc.M212835200. PMID 12716909.
- Sun L, Gong R, Wan B, et al. (2004). "GADD45gamma, down-regulated in 65% hepatocellular carcinoma (HCC) from 23 chinese patients, inhibits cell growth and induces cell cycle G2/M arrest for hepatoma Hep-G2 cell lines.". Mol. Biol. Rep. 30 (4): 249–53. doi:10.1023/A:1026370726763. PMID 14672412.
- Jiang F, Wang Z (2004). "Gadd45gamma is androgen-responsive and growth-inhibitory in prostate cancer cells.". Mol. Cell. Endocrinol. 213 (2): 121–9. doi:10.1016/j.mce.2003.10.050. PMID 15062559.
- Zerbini LF, Wang Y, Czibere A, et al. (2004). "NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival.". Proc. Natl. Acad. Sci. U.S.A. 101 (37): 13618–23. doi:10.1073/pnas.0402069101. PMC 518803. PMID 15353598. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=518803.
- Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
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