GAL3ST1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Galactose-3-O-sulfotransferase 1
Identifiers
Symbols GAL3ST1 ; CST
External IDs OMIM602300 MGI1858277 HomoloGene3574 GeneCards: GAL3ST1 Gene
EC number 2.8.2.11
RNA expression pattern
PBB GE GAL3ST1 205670 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9514 53897
Ensembl ENSG00000128242 ENSMUSG00000049721
UniProt Q99999 Q9JHE4
RefSeq (mRNA) NM_004861 NM_001177691
RefSeq (protein) NP_004852 NP_001171162
Location (UCSC) Chr 22:
30.95 – 30.97 Mb
Chr 11:
3.98 – 4 Mb
PubMed search [1] [2]

Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.[1][2][3]

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.[3]

References[edit]

  1. ^ "Toward a complete human genome sequence". Genome Res 8 (11): 1097–108. Jan 1999. doi:10.1101/gr.8.11.1097. PMID 9847074. 
  2. ^ Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y (Apr 1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase". J Biol Chem 272 (8): 4864–8. doi:10.1074/jbc.272.8.4864. PMID 9030544. 
  3. ^ a b "Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1". 

Further reading[edit]