GAL3ST2

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Galactose-3-O-sulfotransferase 2
Identifiers
Symbols GAL3ST2 ; GAL3ST-2; GP3ST
External IDs OMIM608237 MGI2685834 HomoloGene41471 GeneCards: GAL3ST2 Gene
RNA expression pattern
PBB GE GAL3ST2 gnf1h00397 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 64090 381334
Ensembl ENSG00000154252 ENSMUSG00000094651
UniProt Q9H3Q3 Q6XQH0
RefSeq (mRNA) NM_022134 NM_199366
RefSeq (protein) NP_071417 NP_955398
Location (UCSC) Chr 2:
242.72 – 242.74 Mb
Chr 1:
93.86 – 93.88 Mb
PubMed search [1] [2]

Galactose-3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the GAL3ST2 gene.[1][2]

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2.[2]

References[edit]

  1. ^ Honke K, Tsuda M, Koyota S, Wada Y, Iida-Tanaka N, Ishizuka I, Nakayama J, Taniguchi N (Feb 2001). "Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Gal beta 1-3/1-4GlcNAc-R) oligosaccharides". J Biol Chem 276 (1): 267–74. doi:10.1074/jbc.M005666200. PMID 11029462. 
  2. ^ a b "Entrez Gene: GAL3ST2 galactose-3-O-sulfotransferase 2". 

Further reading[edit]