GAL3ST4

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Galactose-3-O-sulfotransferase 4
Identifiers
Symbols GAL3ST4 ; GAL3ST-4
External IDs OMIM608235 MGI1916254 HomoloGene11633 GeneCards: GAL3ST4 Gene
Orthologs
Species Human Mouse
Entrez 79690 330217
Ensembl ENSG00000197093 ENSMUSG00000075593
UniProt Q96RP7 Q3V1B8
RefSeq (mRNA) NM_024637 NM_001033416
RefSeq (protein) NP_078913 NP_001028588
Location (UCSC) Chr 7:
99.76 – 99.77 Mb
Chr 5:
138.26 – 138.27 Mb
PubMed search [1] [2]

Galactose-3-O-sulfotransferase 4 is an enzyme that in humans is encoded by the GAL3ST4 gene.[1][2]

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate to the C-3' position of galactose residues in O-linked glycoproteins. This enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates.[2]

References[edit]

  1. ^ Seko A, Hara-Kuge S, Yamashita K (Jul 2001). "Molecular cloning and characterization of a novel human galactose 3-O-sulfotransferase that transfers sulfate to gal beta 1-->3galNAc residue in O-glycans". J Biol Chem 276 (28): 25697–704. doi:10.1074/jbc.M101558200. PMID 11333265. 
  2. ^ a b "Entrez Gene: GAL3ST4 galactose-3-O-sulfotransferase 4". 

Further reading[edit]