GALNT6

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Polypeptide N-acetylgalactosaminyltransferase 6
Identifiers
Symbols GALNT6 ; GALNAC-T6; GalNAcT6
External IDs OMIM605148 MGI1891640 HomoloGene5218 GeneCards: GALNT6 Gene
EC number 2.4.1.41
RNA expression pattern
PBB GE GALNT6 219956 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11226 207839
Ensembl ENSG00000139629 ENSMUSG00000037280
UniProt Q8NCL4 Q8C7U7
RefSeq (mRNA) NM_007210 NM_001161767
RefSeq (protein) NP_009141 NP_001155239
Location (UCSC) Chr 12:
51.75 – 51.79 Mb
Chr 15:
100.69 – 100.73 Mb
PubMed search [1] [2]

Polypeptide N-acetylgalactosaminyltransferase 6 is an enzyme that in humans is encoded by the GALNT6 gene.[1][2]

This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin.[2]

References[edit]

  1. ^ Bennett EP, Hassan H, Mandel U, Hollingsworth MA, Akisawa N, Ikematsu Y, Merkx G, van Kessel AG, Olofsson S, Clausen H (Oct 1999). "Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy". J Biol Chem 274 (36): 25362–70. doi:10.1074/jbc.274.36.25362. PMID 10464263. 
  2. ^ a b "Entrez Gene: GALNT6 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)". 

Further reading[edit]