GATA2

GATA binding protein 2
	; PDB rendering based on 1gnf.
Available structures
PDB	1gnf, 1y0j
Identifiers
Symbols	GATA2; DCML; MONOMAC; NFE1B
External IDs	OMIM: 137295 MGI: 95662 HomoloGene: 32030 GeneCards: GATA2 Gene
Gene Ontology
Molecular function	• RNA polymerase II distal enhancer sequence-specific DNA binding; • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; • enhancer sequence-specific DNA binding; • chromatin binding; • sequence-specific DNA binding transcription factor activity; • protein binding; • transcription factor binding; • zinc ion binding; • sequence-specific DNA binding; • metal ion binding; • C2H2 zinc finger domain binding;
Cellular component	• nucleus; • nucleoplasm; • nucleolus; • protein complex;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • urogenital system development; • cell fate determination; • embryonic placenta development; • transcription, DNA-dependent; • blood coagulation; • ventral spinal cord interneuron differentiation; • cell differentiation in hindbrain; • central nervous system neuron development; • pituitary gland development; • somatic stem cell maintenance; • regulation of histone acetylation; • eosinophil fate commitment; • inner ear morphogenesis; • negative regulation of fat cell differentiation; • negative regulation of myeloid cell differentiation; • positive regulation of erythrocyte differentiation; • negative regulation of macrophage differentiation; • positive regulation of megakaryocyte differentiation; • negative regulation of Notch signaling pathway; • positive regulation of angiogenesis; • positive regulation of transcription from RNA polymerase II promoter; • positive regulation of transcription from RNA polymerase II promoter; • positive regulation of transcription from RNA polymerase II promoter; • cell maturation; • neuron fate commitment; • homeostasis of number of cells within a tissue; • positive regulation of phagocytosis; • definitive hemopoiesis; • semicircular canal development; • negative regulation of fat cell proliferation; • negative regulation of neural precursor cell proliferation;
	Sources: Amigo / QuickGO
Orthologs
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GATA binding protein 2, also known as GATA2, is a human gene. The protein encoded by this gene is a transcription factor.^[1]

The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells.^[2] GATA1 is essential for normal primitive and definitive erythropoiesis and is expressed at high levels in erythroid cells, mast cells, and megakaryocytes. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic stem cells. In chicken erythroid progenitors, forced expression of GATA2 promotes proliferation at the expense of differentiation.^[3] GATA3 expression is restricted to T-lymphoid cells and some nonhematopoietic cell types, including embryonic stem cells.^[4]

[edit] Interactions

GATA2 has been shown to interact with Pituitary-specific positive transcription factor 1,^[5] HDAC3,^[6] Zinc finger and BTB domain-containing protein 16,^[7] LMO2,^[8] Promyelocytic leukemia protein^[9] and SPI1.^[10]

[edit] Genetic disorders

Multiple mutations on GATA2 gene have been recently implicated as the cause of primary immunodeficiency in patients with MonoMAC Syndrome, and cases of dendritic cell, monocyte, B NK lymphoid deficiency and leukemia.^[11]

[edit] See also

[edit] References

^ Lee ME, Temizer DH, Clifford JA, Quertermous T (25 August 1991). "Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells". J. Biol. Chem. 266 (24): 16188–92. PMID 1714909. http://www.jbc.org/cgi/content/abstract/266/24/16188.
^ Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH (September 1994). "An early haematopoietic defect in mice lacking the transcription factor GATA-2". Nature 371 (6494): 221–6. doi:10.1038/371221a0. PMID 8078582.
^ Briegel K, Lim KC, Plank C, Beug H, Engel JD, Zenke M (June 1993). "Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner". Genes Dev. 7 (6): 1097–109. doi:10.1101/gad.7.6.1097. PMID 8504932.
^ "Entrez Gene: GATA2 GATA binding protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2624.
^ Dasen, J S; O'Connell S M, Flynn S E, Treier M, Gleiberman A S, Szeto D P, Hooshmand F, Aggarwal A K, Rosenfeld M G (May. 1999). "Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types". Cell (UNITED STATES) 97 (5): 587–98. doi:10.1016/S0092-8674(00)80770-9. ISSN 0092-8674. PMID 10367888.
^ Ozawa, Y; Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, Tanimoto M, Saito H (Oct. 2001). "Histone deacetylase 3 associates with and represses the transcription factor GATA-2". Blood (United States) 98 (7): 2116–23. doi:10.1182/blood.V98.7.2116. ISSN 0006-4971. PMID 11567998.
^ Tsuzuki, Shinobu; Enver Tariq (May. 2002). "Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein". Blood (United States) 99 (9): 3404–10. doi:10.1182/blood.V99.9.3404. ISSN 0006-4971. PMID 11964310.
^ Osada, H; Grutz G, Axelson H, Forster A, Rabbitts T H (Oct. 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. ISSN 0027-8424. PMC 40846. PMID 7568177. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=40846.
^ Tsuzuki, S; Towatari M, Saito H, Enver T (Sep. 2000). "Potentiation of GATA-2 Activity through Interactions with the Promyelocytic Leukemia Protein (PML) and the t(15;17)-Generated PML-Retinoic Acid Receptor α Oncoprotein". Mol. Cell. Biol. (UNITED STATES) 20 (17): 6276–86. doi:10.1128/MCB.20.17.6276-6286.2000. ISSN 0270-7306. PMC 86102. PMID 10938104. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86102.
^ Zhang, P; Behre G, Pan J, Iwama A, Wara-Aswapati N, Radomska H S, Auron P E, Tenen D G, Sun Z (Jul. 1999). "Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (15): 8705–10. doi:10.1073/pnas.96.15.8705. ISSN 0027-8424. PMC 17580. PMID 10411939. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=17580.
^ Dickinson RE, Griffin H, Bigley V, Reynard LN, Hussain R, Haniffa M, Lakey JH, Rahman T, Wang XN, McGovern N, Pagan S, Cookson S, McDonald D, Chua I, Wallis J, Cant A, Wright M, Keavney B, Chinnery PF, Loughlin J, Hambleton S, Santibanez-Koref M, Collin M (September 2011). "Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency". Blood 118 (10): 2656–8. doi:10.1182/blood-2011-06-360313. PMID 21765025.

[edit] Further reading

Minegishi N (2002). "[Transcription factors regulating hematopoiesis: researches spanning from molecule to whole body]". Seikagaku 74 (5): 398–402. PMID 12073612.
Ohneda K, Yamamoto M (2003). "Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage". Acta Haematol. 108 (4): 237–45. doi:10.1159/000065660. PMID 12432220.
Dorfman DM, Wilson DB, Bruns GA, Orkin SH (1992). "Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells". J. Biol. Chem. 267 (2): 1279–85. PMID 1370462.
Page RL, Wharton JM, Wilkinson WE, et al. (1992). "Bidisomide (SC-40230), a new antiarrhythmic agent: initial study of tolerability and pharmacokinetics". Clin. Pharmacol. Ther. 51 (4): 371–8. doi:10.1038/clpt.1992.36. PMID 1563207.
Lee ME, Temizer DH, Clifford JA, Quertermous T (1991). "Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells". J. Biol. Chem. 266 (24): 16188–92. PMID 1714909.
Zhang R, Min W, Sessa WC (1995). "Functional analysis of the human endothelial nitric oxide synthase promoter. Sp1 and GATA factors are necessary for basal transcription in endothelial cells". J. Biol. Chem. 270 (25): 15320–6. doi:10.1074/jbc.270.25.15320. PMID 7541039.
Osada H, Grutz G, Axelson H, et al. (1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=40846.
Towatari M, May GE, Marais R, et al. (1995). "Regulation of GATA-2 phosphorylation by mitogen-activated protein kinase and interleukin-3". J. Biol. Chem. 270 (8): 4101–7. doi:10.1074/jbc.270.8.4101. PMID 7876160.
Tsai FY, Keller G, Kuo FC, et al. (1994). "An early haematopoietic defect in mice lacking the transcription factor GATA-2". Nature 371 (6494): 221–6. doi:10.1038/371221a0. PMID 8078582.
Briegel K, Lim KC, Plank C, et al. (1993). "Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner". Genes Dev. 7 (6): 1097–109. doi:10.1101/gad.7.6.1097. PMID 8504932.
Towatari M, Kanei Y, Saito H, Hamaguchi M (1998). "Hematopoietic transcription factor GATA-2 activates transcription from HIV-1 long terminal repeat". AIDS 12 (3): 253–9. doi:10.1097/00002030-199803000-00002. PMID 9517987.
Dasen JS, O'Connell SM, Flynn SE, et al. (1999). "Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types". Cell 97 (5): 587–98. doi:10.1016/S0092-8674(00)80770-9. PMID 10367888.
Zhang P, Behre G, Pan J, et al. (1999). "Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1". Proc. Natl. Acad. Sci. U.S.A. 96 (15): 8705–10. doi:10.1073/pnas.96.15.8705. PMC 17580. PMID 10411939. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=17580.
Wieser R, Volz A, Vinatzer U, et al. (2000). "Transcription factor GATA-2 gene is located near 3q21 breakpoints in myeloid leukemia". Biochem. Biophys. Res. Commun. 273 (1): 239–45. doi:10.1006/bbrc.2000.2947. PMID 10873593.
Tsuzuki S, Towatari M, Saito H, Enver T (2000). "Potentiation of GATA-2 Activity through Interactions with the Promyelocytic Leukemia Protein (PML) and the t(15;17)-Generated PML-Retinoic Acid Receptor α Oncoprotein". Mol. Cell. Biol. 20 (17): 6276–86. doi:10.1128/MCB.20.17.6276-6286.2000. PMC 86102. PMID 10938104. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86102.
Yamashita K, Discher DJ, Hu J, et al. (2001). "Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP". J. Biol. Chem. 276 (16): 12645–53. doi:10.1074/jbc.M011344200. PMID 11278891.
Ozawa Y, Towatari M, Tsuzuki S, et al. (2001). "Histone deacetylase 3 associates with and represses the transcription factor GATA-2". Blood 98 (7): 2116–23. doi:10.1182/blood.V98.7.2116. PMID 11567998.
Zhang SB, He QY, Zhao H, et al. (2002). "Function of GATA transcription factors in hydroxyurea-induced HEL cells". Cell Res. 11 (4): 301–10. doi:10.1038/sj.cr.7290100. PMID 11787775.
Tsuzuki S, Enver T (2002). "Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein". Blood 99 (9): 3404–10. doi:10.1182/blood.V99.9.3404. PMID 11964310.
Hirasawa R, Shimizu R, Takahashi S, et al. (2002). "Essential and Instructive Roles of GATA Factors in Eosinophil Development". J. Exp. Med. 195 (11): 1379–86. doi:10.1084/jem.20020170. PMC 2193540. PMID 12045236. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193540.

[edit] External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[pmid1714909-0] Lee ME, Temizer DH, Clifford JA, Quertermous T (25 August 1991). "Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells". J. Biol. Chem. 266 (24): 16188–92. PMID 1714909. http://www.jbc.org/cgi/content/abstract/266/24/16188.

[pmid8078582-1] Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH (September 1994). "An early haematopoietic defect in mice lacking the transcription factor GATA-2". Nature 371 (6494): 221–6. doi:10.1038/371221a0. PMID 8078582.

[pmid8504932-2] Briegel K, Lim KC, Plank C, Beug H, Engel JD, Zenke M (June 1993). "Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner". Genes Dev. 7 (6): 1097–109. doi:10.1101/gad.7.6.1097. PMID 8504932.

[entrez-3] "Entrez Gene: GATA2 GATA binding protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2624.

[pmid10367888-4] Dasen, J S; O'Connell S M, Flynn S E, Treier M, Gleiberman A S, Szeto D P, Hooshmand F, Aggarwal A K, Rosenfeld M G (May. 1999). "Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types". Cell (UNITED STATES) 97 (5): 587–98. doi:10.1016/S0092-8674(00)80770-9. ISSN 0092-8674. PMID 10367888.

[pmid11567998-5] Ozawa, Y; Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, Tanimoto M, Saito H (Oct. 2001). "Histone deacetylase 3 associates with and represses the transcription factor GATA-2". Blood (United States) 98 (7): 2116–23. doi:10.1182/blood.V98.7.2116. ISSN 0006-4971. PMID 11567998.

[pmid11964310-6] Tsuzuki, Shinobu; Enver Tariq (May. 2002). "Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein". Blood (United States) 99 (9): 3404–10. doi:10.1182/blood.V99.9.3404. ISSN 0006-4971. PMID 11964310.

[pmid7568177-7] Osada, H; Grutz G, Axelson H, Forster A, Rabbitts T H (Oct. 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. ISSN 0027-8424. PMC 40846. PMID 7568177. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=40846.

[pmid10938104-8] Tsuzuki, S; Towatari M, Saito H, Enver T (Sep. 2000). "Potentiation of GATA-2 Activity through Interactions with the Promyelocytic Leukemia Protein (PML) and the t(15;17)-Generated PML-Retinoic Acid Receptor α Oncoprotein". Mol. Cell. Biol. (UNITED STATES) 20 (17): 6276–86. doi:10.1128/MCB.20.17.6276-6286.2000. ISSN 0270-7306. PMC 86102. PMID 10938104. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86102.

[pmid10411939-9] Zhang, P; Behre G, Pan J, Iwama A, Wara-Aswapati N, Radomska H S, Auron P E, Tenen D G, Sun Z (Jul. 1999). "Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (15): 8705–10. doi:10.1073/pnas.96.15.8705. ISSN 0027-8424. PMC 17580. PMID 10411939. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=17580.

[pmid21765025-10] Dickinson RE, Griffin H, Bigley V, Reynard LN, Hussain R, Haniffa M, Lakey JH, Rahman T, Wang XN, McGovern N, Pagan S, Cookson S, McDonald D, Chua I, Wallis J, Cant A, Wright M, Keavney B, Chinnery PF, Loughlin J, Hambleton S, Santibanez-Koref M, Collin M (September 2011). "Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency". Blood 118 (10): 2656–8. doi:10.1182/blood-2011-06-360313. PMID 21765025.

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GATA2

Contents

[edit] Interactions

[edit] Genetic disorders

[edit] See also

[edit] References

[edit] Further reading

[edit] External links

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