GATA4

GATA binding protein 4
Identifiers
Symbols	GATA4; MGC126629
External IDs	OMIM: 600576 MGI: 95664 HomoloGene: 1551 GeneCards: GATA4 Gene
Gene Ontology
Molecular function	• DNA binding; • sequence-specific DNA binding transcription factor activity; • protein binding; • transcription factor binding; • zinc ion binding; • activating transcription factor binding; • sequence-specific DNA binding; • transcription regulatory region DNA binding; • metal ion binding;
Cellular component	• nucleus; • nucleus; • nucleus; • nucleoplasm;
Biological process	• in utero embryonic development; • gastrulation with mouth forming second; • heart looping; • endocardial cushion development; • cardiac ventricle morphogenesis; • cardiac right ventricle morphogenesis; • ventricular septum development; • atrial septum primum morphogenesis; • atrial septum secundum morphogenesis; • transcription, DNA-dependent; • regulation of transcription, DNA-dependent; • regulation of transcription, DNA-dependent; • transcription from RNA polymerase II promoter; • cell-cell signaling; • endoderm development; • blood coagulation; • male gonad development; • positive regulation vascular endothelial growth factor production; • positive regulation of BMP signaling pathway; • embryonic heart tube anterior/posterior pattern formation; • response to drug; • response to estrogen stimulus; • positive regulation of angiogenesis; • positive regulation of transcription, DNA-dependent; • positive regulation of transcription from RNA polymerase II promoter; • embryonic digestive tract morphogenesis; • embryonic foregut morphogenesis; • positive regulation of cardioblast differentiation; • regulation of cardiac muscle cell proliferation; • SMAD protein signal transduction; • atrial septum morphogenesis; • intestinal epithelial cell differentiation; • cellular response to follicle-stimulating hormone stimulus;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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Transcription factor GATA-4 is a protein that in humans is encoded by the GATA4 gene.^[1]

This gene encodes a member of the GATA family of zinc finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects as well as reproductive defects.^[2]^[3]

[edit] Interactions

GATA4 has been shown to interact with NKX2-5,^[4]^[5]^[6] TBX5,^[4] ZFPM2,^[7] Serum response factor^[8]^[9] and HAND2.^[10] HDAC2^[11]

[edit] See also

GATA transcription factor

[edit] References

^ White RA, Dowler LL, Pasztor LM, Gatson LL, Adkison LR, Angeloni SV, Wilson DB (Oct 1995). "Assignment of the transcription factor GATA4 gene to human chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for Ds (disorganization)". Genomics 27 (1): 20–6. doi:10.1006/geno.1995.1003. PMID 7665171.
^ "Entrez Gene: GATA4 GATA binding protein 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2626.
^ Köhler, B; Lin, L; Ferraz-De-Souza, B; Wieacker, P; Heidemann, P; Schröder, V; Biebermann, H; Schnabel, D et al (2008). "Five novel mutations in steroidogenic factor 1 (SF1, NR5A1) in 46,XY patients with severe underandrogenization but without adrenal insufficiency". Human mutation 29 (1): 59–64. doi:10.1002/humu.20588. PMC 2359628. PMID 17694559. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2359628.
^ ^a ^b Garg, Vidu; Kathiriya Irfan S, Barnes Robert, Schluterman Marie K, King Isabelle N, Butler Cheryl A, Rothrock Caryn R, Eapen Reenu S, Hirayama-Yamada Kayoko, Joo Kunitaka, Matsuoka Rumiko, Cohen Jonathan C, Srivastava Deepak (Jul. 2003). "GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5". Nature (England) 424 (6947): 443–7. doi:10.1038/nature01827. PMID 12845333.
^ Durocher, D; Charron F, Warren R, Schwartz R J, Nemer M (Sep. 1997). "The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors". EMBO J. (ENGLAND) 16 (18): 5687–96. doi:10.1093/emboj/16.18.5687. ISSN 0261-4189. PMC 1170200. PMID 9312027. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170200.
^ Zhu, W; Shiojima I, Hiroi Y, Zou Y, Akazawa H, Mizukami M, Toko H, Yazaki Y, Nagai R, Komuro I (Nov. 2000). "Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease". J. Biol. Chem. (UNITED STATES) 275 (45): 35291–6. doi:10.1074/jbc.M000525200. ISSN 0021-9258. PMID 10948187.
^ Svensson, E C; Tufts R L, Polk C E, Leiden J M (Feb. 1999). "Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (3): 956–61. doi:10.1073/pnas.96.3.956. ISSN 0027-8424. PMC 15332. PMID 9927675. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15332.
^ Belaguli, N S; Sepulveda J L, Nigam V, Charron F, Nemer M, Schwartz R J (Oct. 2000). "Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators". Mol. Cell. Biol. (UNITED STATES) 20 (20): 7550–8. doi:10.1128/MCB.20.20.7550-7558.2000. ISSN 0270-7306. PMC 86307. PMID 11003651. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86307.
^ Morin, S; Paradis P, Aries A, Nemer M (Feb. 2001). "Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor". Mol. Cell. Biol. (United States) 21 (4): 1036–44. doi:10.1128/MCB.21.4.1036-1044.2001. ISSN 0270-7306. PMC 99558. PMID 11158291. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99558.
^ Dai, Yan-Shan; Cserjesi Peter, Markham Bruce E, Molkentin Jeffery D (Jul. 2002). "The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism". J. Biol. Chem. (United States) 277 (27): 24390–8. doi:10.1074/jbc.M202490200. ISSN 0021-9258. PMID 11994297.
^ "Three-way control of fetal heart-cell proliferation could help regenerate cardiac cells". October 7, 2010. http://www.physorg.com/news205686730.html.

[edit] Further reading

Evans T, Reitman M, Felsenfeld G (1988). "An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes". Proc. Natl. Acad. Sci. U.S.A. 85 (16): 5976–80. doi:10.1073/pnas.85.16.5976. PMC 281888. PMID 3413070. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=281888.
Huang WY, Cukerman E, Liew CC (1995). "Identification of a GATA motif in the cardiac alpha-myosin heavy-chain-encoding gene and isolation of a human GATA-4 cDNA". Gene 155 (2): 219–23. doi:10.1016/0378-1119(94)00893-W. PMID 7721094.
Yamagata T, Nishida J, Sakai R et al (1995). "Of the GATA-binding proteins, only GATA-4 selectively regulates the human interleukin-5 gene promoter in interleukin-5-producing cells which express multiple GATA-binding proteins". Mol. Cell. Biol. 15 (7): 3830–9. PMC 230622. PMID 7791790. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230622.
Molkentin JD, Kalvakolanu DV, Markham BE (1994). "Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene". Mol. Cell. Biol. 14 (7): 4947–57. PMC 358867. PMID 8007990. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=358867.
Arceci RJ, King AA, Simon MC et al (1993). "Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart". Mol. Cell. Biol. 13 (4): 2235–46. PMC 359544. PMID 8455608. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=359544.
Huang WY, Heng HH, Liew CC (1997). "Assignment of the human GATA4 gene to 8p23.1→p22 using fluorescence in situ hybridization analysis". Cytogenet. Cell Genet. 72 (2–3): 217–8. doi:10.1159/000134194. PMID 8978781.
Herzig TC, Jobe SM, Aoki H et al (1997). "Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7543–8. doi:10.1073/pnas.94.14.7543. PMC 23858. PMID 9207128. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=23858.
Durocher D, Charron F, Warren R et al (1997). "The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors". EMBO J. 16 (18): 5687–96. doi:10.1093/emboj/16.18.5687. PMC 1170200. PMID 9312027. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170200.
Molkentin JD, Lu JR, Antos CL et al (1998). "A calcineurin-dependent transcriptional pathway for cardiac hypertrophy". Cell 93 (2): 215–28. doi:10.1016/S0092-8674(00)81573-1. PMID 9568714.
Svensson EC, Tufts RL, Polk CE, Leiden JM (1999). "Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes". Proc. Natl. Acad. Sci. U.S.A. 96 (3): 956–61. doi:10.1073/pnas.96.3.956. PMC 15332. PMID 9927675. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15332.
Tremblay JJ, Viger RS (1999). "Transcription factor GATA-4 enhances Müllerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1". Mol. Endocrinol. 13 (8): 1388–401. doi:10.1210/me.13.8.1388. PMID 10446911.
Lin L, Aggarwal S, Glover TW et al (2000). "A minimal critical region of the 8p22-23 amplicon in esophageal adenocarcinomas defined using sequence tagged site-amplification mapping and quantitative polymerase chain reaction includes the GATA-4 gene". Cancer Res. 60 (5): 1341–7. PMID 10728696.
Morin S, Charron F, Robitaille L, Nemer M (2000). "GATA-dependent recruitment of MEF2 proteins to target promoters". EMBO J. 19 (9): 2046–55. doi:10.1093/emboj/19.9.2046. PMC 305697. PMID 10790371. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305697.
Zhu W, Shiojima I, Hiroi Y et al (2001). "Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease". J. Biol. Chem. 275 (45): 35291–6. doi:10.1074/jbc.M000525200. PMID 10948187.
Belaguli NS, Sepulveda JL, Nigam V et al (2000). "Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators". Mol. Cell. Biol. 20 (20): 7550–8. doi:10.1128/MCB.20.20.7550-7558.2000. PMC 86307. PMID 11003651. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86307.
Morin S, Paradis P, Aries A, Nemer M (2001). "Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor". Mol. Cell. Biol. 21 (4): 1036–44. doi:10.1128/MCB.21.4.1036-1044.2001. PMC 99558. PMID 11158291. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99558.
Crispino JD, Lodish MB, Thurberg BL et al (2001). "Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors". Genes Dev. 15 (7): 839–44. doi:10.1101/gad.875201. PMC 312667. PMID 11297508. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=312667.
Dai YS, Markham BE (2001). "p300 Functions as a coactivator of transcription factor GATA-4". J. Biol. Chem. 276 (40): 37178–85. doi:10.1074/jbc.M103731200. PMID 11481322.
Liang Q, Wiese RJ, Bueno OF et al (2001). "The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes". Mol. Cell. Biol. 21 (21): 7460–9. doi:10.1128/MCB.21.21.7460-7469.2001. PMC 99918. PMID 11585926. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99918.

[edit] External links

MeSH GATA4+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on chromosome 8 is a stub. You can help Wikipedia by expanding it.

[pmid7665171-0] White RA, Dowler LL, Pasztor LM, Gatson LL, Adkison LR, Angeloni SV, Wilson DB (Oct 1995). "Assignment of the transcription factor GATA4 gene to human chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for Ds (disorganization)". Genomics 27 (1): 20–6. doi:10.1006/geno.1995.1003. PMID 7665171.

[entrez-1] "Entrez Gene: GATA4 GATA binding protein 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2626.

[2] Köhler, B; Lin, L; Ferraz-De-Souza, B; Wieacker, P; Heidemann, P; Schröder, V; Biebermann, H; Schnabel, D et al (2008). "Five novel mutations in steroidogenic factor 1 (SF1, NR5A1) in 46,XY patients with severe underandrogenization but without adrenal insufficiency". Human mutation 29 (1): 59–64. doi:10.1002/humu.20588. PMC 2359628. PMID 17694559. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2359628.

[pmid12845333-3] Garg, Vidu; Kathiriya Irfan S, Barnes Robert, Schluterman Marie K, King Isabelle N, Butler Cheryl A, Rothrock Caryn R, Eapen Reenu S, Hirayama-Yamada Kayoko, Joo Kunitaka, Matsuoka Rumiko, Cohen Jonathan C, Srivastava Deepak (Jul. 2003). "GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5". Nature (England) 424 (6947): 443–7. doi:10.1038/nature01827. PMID 12845333.

[pmid9312027-4] Durocher, D; Charron F, Warren R, Schwartz R J, Nemer M (Sep. 1997). "The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors". EMBO J. (ENGLAND) 16 (18): 5687–96. doi:10.1093/emboj/16.18.5687. ISSN 0261-4189. PMC 1170200. PMID 9312027. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170200.

[pmid10948187-5] Zhu, W; Shiojima I, Hiroi Y, Zou Y, Akazawa H, Mizukami M, Toko H, Yazaki Y, Nagai R, Komuro I (Nov. 2000). "Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease". J. Biol. Chem. (UNITED STATES) 275 (45): 35291–6. doi:10.1074/jbc.M000525200. ISSN 0021-9258. PMID 10948187.

[pmid9927675-6] Svensson, E C; Tufts R L, Polk C E, Leiden J M (Feb. 1999). "Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (3): 956–61. doi:10.1073/pnas.96.3.956. ISSN 0027-8424. PMC 15332. PMID 9927675. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15332.

[pmid11003651-7] Belaguli, N S; Sepulveda J L, Nigam V, Charron F, Nemer M, Schwartz R J (Oct. 2000). "Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators". Mol. Cell. Biol. (UNITED STATES) 20 (20): 7550–8. doi:10.1128/MCB.20.20.7550-7558.2000. ISSN 0270-7306. PMC 86307. PMID 11003651. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86307.

[pmid11158291-8] Morin, S; Paradis P, Aries A, Nemer M (Feb. 2001). "Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor". Mol. Cell. Biol. (United States) 21 (4): 1036–44. doi:10.1128/MCB.21.4.1036-1044.2001. ISSN 0270-7306. PMC 99558. PMID 11158291. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99558.

[pmid11994297-9] Dai, Yan-Shan; Cserjesi Peter, Markham Bruce E, Molkentin Jeffery D (Jul. 2002). "The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism". J. Biol. Chem. (United States) 277 (27): 24390–8. doi:10.1074/jbc.M202490200. ISSN 0021-9258. PMID 11994297.

[10] "Three-way control of fetal heart-cell proliferation could help regenerate cardiac cells". October 7, 2010. http://www.physorg.com/news205686730.html.

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GATA4

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[edit] Interactions

[edit] See also

[edit] References

[edit] Further reading

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