GATA5

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GATA binding protein 5
Identifiers
Symbols GATA5 ; bB379O24.1
External IDs OMIM611496 MGI109497 HomoloGene32031 GeneCards: GATA5 Gene
Orthologs
Species Human Mouse
Entrez 140628 14464
Ensembl ENSG00000130700 ENSMUSG00000015627
UniProt Q9BWX5 P97489
RefSeq (mRNA) NM_080473 NM_008093
RefSeq (protein) NP_536721 NP_032119
Location (UCSC) Chr 20:
61.04 – 61.05 Mb
Chr 2:
180.33 – 180.33 Mb
PubMed search [1] [2]

Transcription factor GATA-5 is a protein that in humans is encoded by the GATA5 gene.[1][2]

The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.[2]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.