GATA6

From Wikipedia, the free encyclopedia
Jump to: navigation, search
GATA binding protein 6
Identifiers
Symbol GATA6
External IDs OMIM601656 MGI107516 HomoloGene68449 GeneCards: GATA6 Gene
Orthologs
Species Human Mouse
Entrez 2627 14465
Ensembl ENSG00000141448 ENSMUSG00000005836
UniProt Q92908 Q61169
RefSeq (mRNA) NM_005257 NM_010258
RefSeq (protein) NP_005248 NP_034388
Location (UCSC) Chr 18:
19.75 – 19.78 Mb
Chr 18:
11.05 – 11.09 Mb
PubMed search [1] [2]

Transcription factor GATA-6, also known as GATA-binding factor 6 (GATA6), is protein that in humans is encoded by the GATA6 gene.[1] The gene product preferentially binds (A/T/C)GAT(A/T)(A) of the consensus binding sequence.[2]

Clinical significance[edit]

Mutations in the gene have been linked with pancreatic agenesis and congenital heart defects.[3]

See also[edit]

References[edit]

  1. ^ "Entrez Gene: GATA6 GATA binding protein 6". 
  2. ^ Sakai Y, Nakagawa R, Sato R, Maeda M (1998). "Selection of DNA binding sites for human transcriptional regulator GATA-6.". Biochem Biophys Res Commun. 250 (3): 682–688. doi:10.1006/bbrc.1998.9374. PMID 9784406. 
  3. ^ Chao C, McKnight K, Cox K, Chang A, Kim S, Feldman B (2015). "Novel GATA6 Mutations in Patients with Pancreatic Agenesis and Congenital Heart Malformations". PloS One 10 (2): e0118449. doi:10.1371/journal.pone.0118449. PMID 25706805. 


Further reading[edit]

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Suzuki E, Evans T, Lowry J, Truong L, Bell D, Testa J et al. (1997). "The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals". Genomics 38 (3): 283–90. doi:10.1006/geno.1996.0630. PMID 8975704. 
  • Huggon I, Davies A, Gove C, Moscoso G, Moniz C, Foss Y et al. (1997). "Molecular cloning of human GATA-6 DNA binding protein: high levels of expression in heart and gut". Biochim. Biophys. Acta 1353 (2): 98–102. doi:10.1016/s0167-4781(97)00049-3. PMID 9294001. 
  • Yoshida T, Sato R, Mahmood S, Kawasaki S, Futai M, Maeda M (1997). "GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells". FEBS Lett. 414 (2): 333–7. doi:10.1016/S0014-5793(97)01017-X. PMID 9315713. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Wada H, Hasegawa K, Morimoto T, Kakita T, Yanazume T, Sasayama S (2000). "A p300 protein as a coactivator of GATA-6 in the transcription of the smooth muscle-myosin heavy chain gene". J. Biol. Chem. 275 (33): 25330–5. doi:10.1074/jbc.M000828200. PMID 10851229. 
  • Crawford S, Qi C, Misra P, Stellmach V, Rao M, Engel J et al. (2002). "Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors". J. Biol. Chem. 277 (5): 3585–92. doi:10.1074/jbc.M107995200. PMID 11724781. 
  • Liu C, Glasser S, Wan H, Whitsett J (2002). "GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression". J. Biol. Chem. 277 (6): 4519–25. doi:10.1074/jbc.M107585200. PMID 11733512. 
  • Kiiveri S, Liu J, Westerholm-Ormio M, Narita N, Wilson D, Voutilainen R et al. (2003). "Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development". Endocr. Res. 28 (4): 647–50. doi:10.1081/ERC-120016980. PMID 12530677. 
  • Chang D, Belaguli N, Iyer D, Roberts W, Wu S, Dong X et al. (2003). "Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors". Dev. Cell 4 (1): 107–18. doi:10.1016/S1534-5807(02)00396-9. PMID 12530967. 
  • Nemer G, Nemer M (2003). "Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6". Dev. Biol. 254 (1): 131–48. doi:10.1016/S0012-1606(02)00026-X. PMID 12606287. 
  • Abe M, Hasegawa K, Wada H, Morimoto T, Yanazume T, Kawamura T et al. (2003). "GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells". Arterioscler. Thromb. Vasc. Biol. 23 (3): 404–10. doi:10.1161/01.ATV.0000059405.51042.A0. PMID 12615657. 
  • Ketola I, Toppari J, Vaskivuo T, Herva R, Tapanainen J, Heikinheimo M (2003). "Transcription factor GATA-6, cell proliferation, apoptosis, and apoptosis-related proteins Bcl-2 and Bax in human fetal testis". J. Clin. Endocrinol. Metab. 88 (4): 1858–65. doi:10.1210/jc.2002-021647. PMID 12679484. 
  • Siltanen S, Heikkilä P, Bielinska M, Wilson D, Heikinheimo M (2004). "Transcription factor GATA-6 is expressed in malignant endoderm of pediatric yolk sac tumors and in teratomas". Pediatr. Res. 54 (4): 542–6. doi:10.1203/01.PDR.0000081295.56529.E9. PMID 12867597. 
  • Liu C, Ikegami M, Stahlman M, Dey C, Whitsett J (2003). "Inhibition of alveolarization and altered pulmonary mechanics in mice expressing GATA-6". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (6): L1246–54. doi:10.1152/ajplung.00443.2002 (inactive 2015-01-01). PMID 12909592. 
  • Benchabane H, Wrana J (2003). "GATA- and Smad1-Dependent Enhancers in the Smad7 Gene Differentially Interpret Bone Morphogenetic Protein Concentrations". Mol. Cell. Biol. 23 (18): 6646–61. doi:10.1128/MCB.23.18.6646-6661.2003. PMC 193708. PMID 12944489. 
  • Jimenez P, Saner K, Mayhew B, Rainey W (2003). "GATA-6 is expressed in the human adrenal and regulates transcription of genes required for adrenal androgen biosynthesis". Endocrinology 144 (10): 4285–8. doi:10.1210/en.2003-0472. PMID 12959982. 
  • Saner K, Suzuki T, Sasano H, Pizzey J, Ho C, Strauss J et al. (2005). "Steroid sulfotransferase 2A1 gene transcription is regulated by steroidogenic factor 1 and GATA-6 in the human adrenal". Mol. Endocrinol. 19 (1): 184–97. doi:10.1210/me.2003-0332. PMID 15388788. 
  • Kiiveri S, Liu J, Heikkilä P, Arola J, Lehtonen E, Voutilainen R et al. (2005). "Transcription factors GATA-4 and GATA-6 in human adrenocortical tumors". Endocr. Res. 30 (4): 919–23. doi:10.1081/ERC-200044149. PMID 15666845. 

External links[edit]