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Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Symbols GBGT1 ; A3GALNT; FS; UNQ2513
External IDs OMIM606074 MGI2449143 HomoloGene110677 GeneCards: GBGT1 Gene
EC number
Species Human Mouse
Entrez 26301 227671
Ensembl ENSG00000148288 ENSMUSG00000026829
UniProt Q8N5D6 Q8VI38
RefSeq (mRNA) NM_001282629 NM_139197
RefSeq (protein) NP_001269558 NP_631936
Location (UCSC) Chr 9:
136.03 – 136.04 Mb
Chr 2:
28.5 – 28.51 Mb
PubMed search [1] [2]

Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the GBGT1 gene.[1][2][3]

This gene encodes a member of the histo-blood group ABO gene family that encodes glycosyltransferases with related but distinct substrate specificity. This protein plays a role in synthesizing Forssman glycolipid (FG), a member of the globoseries glycolipid family. Human cells do not normally produce FG but produce the precursor glycolipids globotriaosylceramide and globoside. This protein may be involved in the tropism and binding of pathogenic organisms.[3]


  1. ^ Xu H, Storch T, Yu M, Elliott SP, Haslam DB (Nov 1999). "Characterization of the human Forssman synthetase gene. An evolving association between glycolipid synthesis and host-microbial interactions". J Biol Chem 274 (41): 29390–8. doi:10.1074/jbc.274.41.29390. PMID 10506200. 
  2. ^ Haslam DB, Baenziger JU (Nov 1996). "Expression cloning of Forssman glycolipid synthetase: a novel member of the histo-blood group ABO gene family". Proc Natl Acad Sci U S A 93 (20): 10697–702. doi:10.1073/pnas.93.20.10697. PMC 38217. PMID 8855242. 
  3. ^ a b "Entrez Gene: GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1". 

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