GCA (gene)

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Grancalcin, EF-hand calcium binding protein
Protein GCA PDB 1f4o.png
PDB rendering based on 1f4o.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GCA ; GCL
External IDs OMIM607030 MGI1918521 HomoloGene22702 GeneCards: GCA Gene
RNA expression pattern
PBB GE GCA 203765 at tn.png
More reference expression data
Species Human Mouse
Entrez 25801 227960
Ensembl ENSG00000115271 ENSMUSG00000026893
UniProt P28676 Q8VC88
RefSeq (mRNA) NM_012198 NM_145523
RefSeq (protein) NP_036330 NP_663498
Location (UCSC) Chr 2:
163.18 – 163.23 Mb
Chr 2:
62.66 – 62.69 Mb
PubMed search [1] [2]

Grancalcin is a protein that in humans is encoded by the GCA gene.[1][2][3][4]

This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.[4]


GCA (gene) has been shown to interact with SRI.[3]


  1. ^ Boyhan A, Casimir CM, French JK, Teahan CG, Segal AW (Mar 1992). "Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes". J Biol Chem 267 (5): 2928–33. PMID 1737748. 
  2. ^ Teahan CG, Totty NF, Segal AW (Oct 1992). "Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils". Biochem J. 286. ( Pt 2): 549–54. PMC 1132932. PMID 1530588. 
  3. ^ a b Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW (Jun 2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Lett 545 (2-3): 151–4. doi:10.1016/S0014-5793(03)00518-0. PMID 12804766. 
  4. ^ a b "Entrez Gene: GCA grancalcin, EF-hand calcium binding protein". 

Further reading[edit]