GCA (gene)

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Grancalcin, EF-hand calcium binding protein
Protein GCA PDB 1f4o.png
PDB rendering based on 1f4o.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GCA ; GCL
External IDs OMIM607030 MGI1918521 HomoloGene22702 GeneCards: GCA Gene
RNA expression pattern
PBB GE GCA 203765 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 25801 227960
Ensembl ENSG00000115271 ENSMUSG00000026893
UniProt P28676 Q8VC88
RefSeq (mRNA) NM_012198 NM_145523
RefSeq (protein) NP_036330 NP_663498
Location (UCSC) Chr 2:
163.18 – 163.23 Mb
Chr 2:
62.66 – 62.69 Mb
PubMed search [1] [2]

Grancalcin is a protein that in humans is encoded by the GCA gene.[1][2][3][4]

This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.[4]

Interactions[edit]

GCA (gene) has been shown to interact with SRI.[3]

References[edit]

  1. ^ Boyhan A, Casimir CM, French JK, Teahan CG, Segal AW (Mar 1992). "Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes". J Biol Chem 267 (5): 2928–33. PMID 1737748. 
  2. ^ Teahan CG, Totty NF, Segal AW (Oct 1992). "Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils". Biochem J. 286. ( Pt 2): 549–54. PMC 1132932. PMID 1530588. 
  3. ^ a b Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW (Jun 2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Lett 545 (2-3): 151–4. doi:10.1016/S0014-5793(03)00518-0. PMID 12804766. 
  4. ^ a b "Entrez Gene: GCA grancalcin, EF-hand calcium binding protein". 

Further reading[edit]