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For the post-nomial, see Legion of Merit (Rhodesia).
Glutamate-cysteine ligase, modifier subunit
Symbols GCLM ; GLCLR
External IDs OMIM601176 MGI104995 HomoloGene1557 GeneCards: GCLM Gene
EC number
RNA expression pattern
PBB GE GCLM 203925 at tn.png
More reference expression data
Species Human Mouse
Entrez 2730 14630
Ensembl ENSG00000023909 ENSMUSG00000028124
UniProt P48507 O09172
RefSeq (mRNA) NM_002061 NM_008129
RefSeq (protein) NP_002052 NP_032155
Location (UCSC) Chr 1:
94.35 – 94.37 Mb
Chr 3:
122.25 – 122.27 Mb
PubMed search [1] [2]

Glutamate-cysteine ligase regulatory subunit is an enzyme that in humans is encoded by the GCLM gene.[1][2]

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.[2]


  1. ^ Gipp JJ, Bailey HH, Mulcahy RT (Feb 1995). "Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues". Biochem Biophys Res Commun 206 (2): 584–9. doi:10.1006/bbrc.1995.1083. PMID 7826375. 
  2. ^ a b "Entrez Gene: GCLM glutamate-cysteine ligase, modifier subunit". 

Further reading[edit]