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Mannosyl-oligosaccharide glucosidase
Symbols MOGS ; CDG2B; CWH41; DER7; GCS1
External IDs OMIM601336 MGI1929872 HomoloGene4593 ChEMBL: 4684 GeneCards: MOGS Gene
EC number
RNA expression pattern
PBB GE GCS1 210627 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7841 57377
Ensembl ENSG00000115275 ENSMUSG00000030036
UniProt Q13724 Q80UM7
RefSeq (mRNA) NM_001146158 NM_020619
RefSeq (protein) NP_001139630 NP_065644
Location (UCSC) Chr 2:
74.69 – 74.69 Mb
Chr 6:
83.12 – 83.12 Mb
PubMed search [1] [2]

Mannosyl-oligosaccharide glucosidase is an enzyme that in humans is encoded by the MOGS gene.[1][2][3]

Glucosidase I is the first enzyme in the N-linked oligosaccharide processing pathway. GCS1 cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. GCS1 is located in the lumen of the endoplasmic reticulum.[3]

GCS1 may also refer to "generative cell specific 1", also called HAP2 (hapless2), a gene of lower eukaryotes which is thought to be responsible for gametes fusion .[4] .


  1. ^ Kalz-Fuller B, Bieberich E, Bause E (Sep 1995). "Sexualization and expression of glucosidase I from human hippocampus". Eur J Biochem 231 (2): 344–51. doi:10.1111/j.1432-1033.1995.tb20706.x. PMID 7635146. 
  2. ^ Kalz-Fuller B, Heidrich-Kaul C, Nothen M, Bause E, Schwanitz G (Sep 1996). "Localization of the human glucosidase I gene to chromosome 2p12-p13 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids". Genomics 34 (3): 442–3. doi:10.1006/geno.1996.0313. PMID 8786151. 
  3. ^ a b "Entrez Gene: GCS1 glucosidase I". 
  4. ^ "Gamete Fusion: Key Protein Identified". Retrieved 06.05.09. 

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