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GDC may refer to:
- Game Developers Conference, a popular annual video game conference
- Gadolinium doped ceria, a ceramic electrolyte used in solid oxide fuel cells
- General Development Corporation
- General Dental Council
- Gross Dealer Concession
- Guglielmi Detachable Coil, a platinum coil commonly used for the occlusion of brain aneurysms
- Society of Graphic Designers of Canada
- Graphics Display Controller, for example, NEC µPD7220
- GDC, a D (programming language) front-end for the GNU Compiler Collection
- Virginia General District Court
- Gravity Discovery Centre, Gingin, Western Australia
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