GDF7

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Growth differentiation factor 7
Identifiers
Symbols GDF7 ; BMP12
External IDs OMIM604651 MGI95690 HomoloGene32177 GeneCards: GDF7 Gene
Orthologs
Species Human Mouse
Entrez 151449 238057
Ensembl ENSG00000143869 ENSMUSG00000037660
UniProt Q7Z4P5 P43029
RefSeq (mRNA) NM_182828 NM_013527
RefSeq (protein) NP_878248 NP_038555
Location (UCSC) Chr 2:
20.87 – 20.87 Mb
Chr 12:
8.3 – 8.3 Mb
PubMed search [1] [2]

Growth differentiation factor 7 (GDF7) is a protein that in humans is encoded by the GDF7 gene.[1]

GDF7 belongs to the transforming growth factor beta superfamily that is specifically found in a signaling center known as the roof plate that is located in the developing nervous system of embryos. The roof plate is required for the generation of several classes of spinal cord dorsal interneurons; GDF7 specifically induces the formation of sensory neurons in the dorsal spinal cord from neural crest cells by generating signals within the roof plate.[1][2]

References[edit]

Further reading[edit]

  • Davila S, Froeling FE, Tan A et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. 
  • Davidson AJ, Postlethwait JH, Yan YL et al. (1999). "Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily". Genome Res. 9 (2): 121–9. doi:10.1101/gr.9.2.121. PMID 10022976. 
  • Butler SJ, Dodd J (2003). "A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons". Neuron 38 (3): 389–401. doi:10.1016/S0896-6273(03)00254-X. PMID 12741987. 
  • Mazerbourg S, Sangkuhl K, Luo CW et al. (2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". J. Biol. Chem. 280 (37): 32122–32. doi:10.1074/jbc.M504629200. PMID 16049014.