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Gem (nuclear organelle) associated protein 5
Symbols GEMIN5 ; GEMIN-5
External IDs OMIM607005 MGI2449311 HomoloGene9155 GeneCards: GEMIN5 Gene
RNA expression pattern
PBB GE GEMIN5 gnf1h01818 at tn.png
PBB GE GEMIN5 gnf1h07897 at tn.png
PBB GE GEMIN5 gnf1h07920 at tn.png
More reference expression data
Species Human Mouse
Entrez 25929 216766
Ensembl ENSG00000082516 ENSMUSG00000037275
UniProt Q8TEQ6 Q8BX17
RefSeq (mRNA) NM_001252156 NM_001166669
RefSeq (protein) NP_001239085 NP_001160141
Location (UCSC) Chr 5:
154.27 – 154.32 Mb
Chr 11:
58.12 – 58.17 Mb
PubMed search [1] [2]

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.[1][2]


GEMIN5 is part of a large macromolecular complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), and GEMIN4 (MIM 606969).[2]


GEMIN5 has been shown to interact with DDX20[1][3] and SMN1.[1]


  1. ^ a b c Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (Feb 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J Biol Chem 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716. 
  2. ^ a b "Entrez Gene: GEMIN5 gem (nuclear organelle) associated protein 5". 
  3. ^ Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L et al. (Mar 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365. PMID 11914277. 

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