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GDNF family receptor alpha 3
Protein GFRA3 PDB 2gh0.png
PDB rendering based on 2gh0.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GFRA3 ; GDNFR3
External IDs OMIM605710 MGI1201403 HomoloGene1146 IUPHAR: 1745 GeneCards: GFRA3 Gene
RNA expression pattern
PBB GE GFRA3 214479 at tn.png
More reference expression data
Species Human Mouse
Entrez 2676 14587
Ensembl ENSG00000146013 ENSMUSG00000024366
UniProt O60609 O35118
RefSeq (mRNA) NM_001496 NM_010280
RefSeq (protein) NP_001487 NP_034410
Location (UCSC) Chr 5:
137.59 – 137.61 Mb
Chr 18:
34.69 – 34.72 Mb
PubMed search [1] [2]

GDNF family receptor alpha-3 (GFRα3), also known as the artemin receptor, is a protein that in humans is encoded by the GFRA3 gene.[1][2]


The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.[2]

See also[edit]


  1. ^ Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T et al. (Dec 1997). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". The Journal of Biological Chemistry 272 (52): 33111–7. doi:10.1074/jbc.272.52.33111. PMID 9407096. 
  2. ^ a b "Entrez Gene: GFRA3 GDNF family receptor alpha 3". 

Further reading[edit]