From Wikipedia, the free encyclopedia
Jump to: navigation, search
Golgi-associated, gamma adaptin ear containing, ARF binding protein 1
Protein GGA1 PDB 1j2j.png
PDB rendering based on 1j2j.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol GGA1
External IDs OMIM606004 MGI2146207 HomoloGene39250 GeneCards: GGA1 Gene
RNA expression pattern
PBB GE GGA1 45572 s at tn.png
PBB GE GGA1 50277 at tn.png
PBB GE GGA1 218114 at tn.png
More reference expression data
Species Human Mouse
Entrez 26088 106039
Ensembl ENSG00000100083 ENSMUSG00000033128
UniProt Q9UJY5 Q8R0H9
RefSeq (mRNA) NM_001001560 NM_145929
RefSeq (protein) NP_001001560 NP_666041
Location (UCSC) Chr 22:
38 – 38.03 Mb
Chr 15:
78.88 – 78.89 Mb
PubMed search [1] [2]

ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene.[1][2][3]

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[4]


GGA1 has been shown to interact with Sortilin 1,[5] BACE2,[6] RABEP1[7] and ARF3.[8][9]


  1. ^ Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (May 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". J Cell Biol 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088. 
  2. ^ Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS (May 2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". J Cell Biol 149 (1): 81–94. doi:10.1083/jcb.149.1.81. PMC 2175099. PMID 10747089. 
  3. ^ Xie L, Boyle D, Sanford D, Scherer PE, Pessin JE, Mora S (March 2006). "Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles". J Biol Chem 281 (11): 7253–9. doi:10.1074/jbc.M511313200. PMID 16407204. 
  4. ^ "Entrez Gene: GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1". 
  5. ^ Jacobsen, Linda; Madsen Peder; Nielsen Morten S; Geraerts Wijnand P M; Gliemann Jørgen; Smit August B; Petersen Claus M (January 2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Lett. (Netherlands) 511 (1-3): 155–8. doi:10.1016/S0014-5793(01)03299-9. ISSN 0014-5793. PMID 11821067. 
  6. ^ He, Xiangyuan; Chang Wan-Pin; Koelsch Gerald; Tang Jordan (July 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Lett. (Netherlands) 524 (1-3): 183–7. doi:10.1016/S0014-5793(02)03052-1. ISSN 0014-5793. PMID 12135764. 
  7. ^ Mattera, Rafael; Arighi Cecilia N; Lodge Robert; Zerial Marino; Bonifacino Juan S (January 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. (England) 22 (1): 78–88. doi:10.1093/emboj/cdg015. ISSN 0261-4189. PMC 140067. PMID 12505986. 
  8. ^ Boman, Annette L; Salo Paul D; Hauglund Melissa J; Strand Nicole L; Rensink Shelly J; Zhdankina Olga (September 2002). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Mol. Biol. Cell (United States) 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. ISSN 1059-1524. PMC 124144. PMID 12221117. 
  9. ^ Boman, A L; Zhang C j; Zhu X; Kahn R A (April 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Mol. Biol. Cell (UNITED STATES) 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. ISSN 1059-1524. PMC 14844. PMID 10749927. 

Further reading[edit]