Gamma-glutamyltransferase-like activity 1 (GGTLA1) is a member of a gene family with at least 4 members (GGTLA1, GGTLA2, GGTLA3 and GGTLA4). The enzyme encoded by GGTLA1 is related to, but distinct from, gamma-glutamyl transpeptidase (GGT). The GGTLA1 enzyme consists of a heavy and a light chain and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay GGT. Its amino acid sequence shows an overall similarity of 39.5% with human GGT.
^Morris C, Courtay C, Geurts van Kessel A, ten Hoeve J, Heisterkamp N, Groffen J (Apr 1993). "Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22". Hum Genet91 (1): 31–6. PMID8095916.
Enoiu M, Aberkane H, Salazar JF, et al. (2000). "Evidence for the pro-oxidant effect of gamma-glutamyltranspeptidase-related enzyme.". Free Radic. Biol. Med.29 (9): 825–33. doi:10.1016/S0891-5849(00)00370-1. PMID11063908.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature402 (6761): 489–95. doi:10.1038/990031. PMID10591208.
Potdar PD, Andrews KL, Nettesheim P, Ostrowski LE (1997). "Expression and regulation of gamma-glutamyl transpeptidase-related enzyme in tracheal cells.". Am. J. Physiol.273 (5 Pt 1): L1082–9. PMID9374738.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.