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Gamma-glutamyltransferase 5
Symbols GGT5 ; GGT-REL; GGTLA1
External IDs OMIM137168 MGI1346063 HomoloGene55802 GeneCards: GGT5 Gene
EC number,,
RNA expression pattern
PBB GE GGTLA1 205582 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2687 23887
Ensembl ENSG00000099998 ENSMUSG00000006344
UniProt P36269 Q9Z2A9
RefSeq (mRNA) NM_001099781 NM_011820
RefSeq (protein) NP_001093251 NP_035950
Location (UCSC) Chr 22:
24.62 – 24.64 Mb
Chr 10:
75.59 – 75.62 Mb
PubMed search [1] [2]

Gamma-glutamyltransferase 5 is an enzyme that in humans is encoded by the GGT5 gene.[1][2][3][4]

Gamma-glutamyltransferase-like activity 1 (GGTLA1) is a member of a gene family with at least 4 members (GGTLA1, GGTLA2, GGTLA3 and GGTLA4). The enzyme encoded by GGTLA1 is related to, but distinct from, gamma-glutamyl transpeptidase (GGT). The GGTLA1 enzyme consists of a heavy and a light chain and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay GGT. Its amino acid sequence shows an overall similarity of 39.5% with human GGT.[4]


  1. ^ Heisterkamp N, Rajpert-De Meyts E, Uribe L, Forman HJ, Groffen J (Aug 1991). "Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase". Proc Natl Acad Sci U S A 88 (14): 6303–7. doi:10.1073/pnas.88.14.6303. PMC 52071. PMID 1676842. 
  2. ^ Morris C, Courtay C, Geurts van Kessel A, ten Hoeve J, Heisterkamp N, Groffen J (Apr 1993). "Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22". Hum Genet 91 (1): 31–6. doi:10.1007/bf00230218. PMID 8095916. 
  3. ^ Heisterkamp N, Groffen J, Warburton D, Sneddon TP (Apr 2008). "The human gamma-glutamyltransferase gene family". Hum Genet 123 (4): 321–32. doi:10.1007/s00439-008-0487-7. PMID 18357469. 
  4. ^ a b "Entrez Gene: GGTLA1 gamma-glutamyltransferase-like activity 1". 

Further reading[edit]