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GHB may refer to:
- gamma-Hydroxybutyric acid, a depressant drug that is illegal in a number of countries
- glycated hemoglobin, a form of hemoglobin created during its exposure to high plasma levels of glucose
- Gabo d'Hirutho d'Bethnahrin, a militant Assyrian party labeled by the Turkish Government as a terrorist group
- Great Highland Bagpipe, a variety of bagpipe
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