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GIPC PDZ domain containing family, member 1
External IDs OMIM605072 MGI1926252 HomoloGene21167 GeneCards: GIPC1 Gene
RNA expression pattern
PBB GE GIPC1 207525 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10755 67903
Ensembl ENSG00000123159 ENSMUSG00000019433
UniProt O14908 Q9Z0G0
RefSeq (mRNA) NM_005716 NM_018771
RefSeq (protein) NP_005707 NP_061241
Location (UCSC) Chr 19:
14.59 – 14.61 Mb
Chr 8:
83.65 – 83.66 Mb
PubMed search [1] [2]

GIPC PDZ domain containing family, member 1 (GIPC1) is a protein that in humans is encoded by the GIPC1 gene.[1][2][3]


GIPC1 has been shown to interact with Beta-1 adrenergic receptor,[4] ITGA5,[5] ITGA6,[5] TPBG,[6] RGS19,[7] TYRP1,[8] GLUT1,[9] Actinin, alpha 1,[9] KIF1B,[9] LRP2,[10][11][12] Luteinizing hormone/choriogonadotropin receptor,[13] LRP1[10] and MYO6.[14][15]

See also[edit]

GIPC PDZ domain containing family, member 2, GIPC2

GIPC PDZ domain containing family, member 3, GIPC3


  1. ^ De Vries L, Lou X, Zhao G, Zheng B, Farquhar MG (November 1998). "GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP". Proc Natl Acad Sci U S A 95 (21): 12340–5. doi:10.1073/pnas.95.21.12340. PMC 22833. PMID 9770488. 
  2. ^ Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (March 1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins". Oncogene 16 (5): 643–54. doi:10.1038/sj.onc.1201567. PMID 9482110. 
  3. ^ "Entrez Gene: GIPC1 GIPC PDZ domain containing family, member 1". 
  4. ^ Hu, Liaoyuan A; Chen Wei; Martin Negin P; Whalen Erin J; Premont Richard T; Lefkowitz Robert J (July 2003). "GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation". J. Biol. Chem. (United States) 278 (28): 26295–301. doi:10.1074/jbc.M212352200. ISSN 0021-9258. PMID 12724327. 
  5. ^ a b Tani, T T; Mercurio A M (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol. Chem. (United States) 276 (39): 36535–42. doi:10.1074/jbc.M105785200. ISSN 0021-9258. PMID 11479315. 
  6. ^ Awan, Abida; Lucic Melinda R; Shaw David M; Sheppard Freda; Westwater Caroline; Lyons Steve A; Stern Peter L (January 2002). "5T4 interacts with TIP-2/GIPC, a PDZ protein, with implications for metastasis". Biochem. Biophys. Res. Commun. (United States) 290 (3): 1030–6. doi:10.1006/bbrc.2001.6288. ISSN 0006-291X. PMID 11798178. 
  7. ^ Lou, X; Yano H; Lee F; Chao M V; Farquhar M G (March 2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways". Mol. Biol. Cell (United States) 12 (3): 615–27. doi:10.1091/mbc.12.3.615. ISSN 1059-1524. PMC 30968. PMID 11251075. 
  8. ^ Liu, T F; Kandala G; Setaluri V (September 2001). "PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1)". J. Biol. Chem. (United States) 276 (38): 35768–77. doi:10.1074/jbc.M103585200. ISSN 0021-9258. PMID 11441007. 
  9. ^ a b c Bunn, R C; Jensen M A; Reed B C (April 1999). "Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton". Mol. Biol. Cell (UNITED STATES) 10 (4): 819–32. doi:10.1091/mbc.10.4.819. ISSN 1059-1524. PMC 25204. PMID 10198040. 
  10. ^ a b Gotthardt, M; Trommsdorff M; Nevitt M F; Shelton J; Richardson J A; Stockinger W; Nimpf J; Herz J (August 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. (UNITED STATES) 275 (33): 25616–24. doi:10.1074/jbc.M000955200. ISSN 0021-9258. PMID 10827173. 
  11. ^ Petersen, Helle Heibroch; Hilpert Jan; Militz Daniel; Zandler Valerie; Jacobsen Christian; Roebroek Anton J M; Willnow Thomas E (February 2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell. Sci. (England) 116 (Pt 3): 453–61. doi:10.1242/jcs.00243. ISSN 0021-9533. PMID 12508107. 
  12. ^ Lou, Xiaojing; McQuistan Tammie; Orlando Robert A; Farquhar Marilyn Gist (April 2002). "GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function". J. Am. Soc. Nephrol. (United States) 13 (4): 918–27. ISSN 1046-6673. PMID 11912251. 
  13. ^ Hirakawa, Takashi; Galet Colette; Kishi Mikiko; Ascoli Mario (December 2003). "GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR". J. Biol. Chem. (United States) 278 (49): 49348–57. doi:10.1074/jbc.M306557200. ISSN 0021-9258. PMID 14507927. 
  14. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  15. ^ Aschenbrenner, Laura; Lee TinThu; Hasson Tama (July 2003). "Myo6 facilitates the translocation of endocytic vesicles from cell peripheries". Mol. Biol. Cell (United States) 14 (7): 2728–43. doi:10.1091/mbc.E02-11-0767. ISSN 1059-1524. PMC 165672. PMID 12857860. 

Further reading[edit]