GJD4

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Gap junction protein, delta 4, 40.1kDa
Identifiers
Symbols GJD4 ; CX40.1; RP11-425A6.2
External IDs OMIM611922 MGI2444990 HomoloGene17692 IUPHAR: Cx40.1 GeneCards: GJD4 Gene
Orthologs
Species Human Mouse
Entrez 219770 225152
Ensembl ENSG00000177291 ENSMUSG00000036855
UniProt Q96KN9 Q8BSD4
RefSeq (mRNA) NM_153368 NM_153086
RefSeq (protein) NP_699199 NP_694726
Location (UCSC) Chr 10:
35.89 – 35.9 Mb
Chr 18:
9.28 – 9.28 Mb
PubMed search [1] [2]

Gap junction delta-4 protein (GJD4), also known as connexin-40.1 (Cx40.1), is a protein that in humans is encoded by the GJD4 gene.[1]

Function[edit]

Connexins, such as GJD4, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits.[1][2]

References[edit]

  1. ^ a b "Entrez Gene: gap junction protein". 
  2. ^ Söhl G, Nielsen PA, Eiberger J, Willecke K (2003). "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues". Cell Commun. Adhes. 10 (1): 27–36. doi:10.1080/15419060302063. PMID 12881038. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.