GLRB

Glycine receptor, beta
PDB rendering based on 1t3e.
Available structures PDB 1t3e
Identifiers
Symbols	GLRB;
External IDs	OMIM: 138492 MGI: 95751 HomoloGene: 20224 IUPHAR: β GeneCards: GLRB Gene
Gene Ontology Molecular function • receptor activity • ion channel activity • extracellular ligand-gated ion channel activity • protein binding • glycine binding • extracellular-glycine-gated ion channel activity • extracellular-glycine-gated chloride channel activity • extracellular-glycine-gated chloride channel activity Cellular component • membrane fraction • plasma membrane • integral to plasma membrane • cell junction • chloride channel complex • synapse • postsynaptic membrane Biological process • startle response • ion transport • neuropeptide signaling pathway • synaptic transmission • acrosome reaction • nervous system development • visual perception • adult walking behavior • ion transmembrane transport • regulation of membrane potential • protein heterooligomerization • transmembrane transport • synaptic transmission, glycinergic • righting reflex Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2743	14658
Ensembl	ENSG00000109738	ENSMUSG00000028020
UniProt	P48167	O54848
RefSeq (mRNA)	NM_000824.4	NM_010298.5
RefSeq (protein)	NP_000815.1	NP_034428.2
Location (UCSC)	Chr 4: 158 – 158.09 Mb	Chr 3: 80.65 – 80.72 Mb
PubMed search	[1]	[2]

Glycine receptor subunit beta is a protein that in humans is encoded by the GLRB gene.

The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM]

See also

• Glycine receptor

Further reading

• Meyer G, Kirsch J, Betz H, Langosch D (1995). "Identification of a gephyrin binding motif on the glycine receptor beta subunit". Neuron 15 (3): 563–72. doi:10.1016/0896-6273(95)90145-0. PMID 7546736. 
• Sarang SS, Miller GW, Grant DF, Schnellmann RG (1999). "Expression and localization of the neuronal glycine receptor beta-subunit in human, rabbit and rat kidneys". Nephron 82 (3): 254–60. doi:10.1159/000045410. PMID 10395998. 
• Rees MI, Lewis TM, Kwok JB, et al. (2002). "Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB)". Hum. Mol. Genet. 11 (7): 853–60. doi:10.1093/hmg/11.7.853. PMID 11929858. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Chen Z, Dillon GH, Huang R (2004). "Molecular determinants of proton modulation of glycine receptors". J. Biol. Chem. 279 (2): 876–83. doi:10.1074/jbc.M307684200. PMID 14563849. 
• Burzomato V, Groot-Kormelink PJ, Sivilotti LG, Beato M (2004). "Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation". Recept. Channels 9 (6): 353–61. PMID 14698963. 
• Harvey K, Duguid IC, Alldred MJ, et al. (2004). "The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering". J. Neurosci. 24 (25): 5816–26. doi:10.1523/JNEUROSCI.1184-04.2004. PMID 15215304. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Grudzinska J, Schemm R, Haeger S, et al. (2005). "The beta subunit determines the ligand binding properties of synaptic glycine receptors". Neuron 45 (5): 727–39. doi:10.1016/j.neuron.2005.01.028. PMID 15748848. 

External links

• MeSH GLRB+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.