GNA12

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Guanine nucleotide binding protein (G protein) alpha 12
Protein GNA12 PDB 1zca.png
PDB rendering based on 1zca.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GNA12 ; NNX3; RMP; gep
External IDs OMIM604394 MGI95767 HomoloGene22398 GeneCards: GNA12 Gene
RNA expression pattern
PBB GE GNA12 221737 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2768 14673
Ensembl ENSG00000146535 ENSMUSG00000000149
UniProt Q03113 P27600
RefSeq (mRNA) NM_007353 NM_010302
RefSeq (protein) NP_031379 NP_034432
Location (UCSC) Chr 7:
2.77 – 2.88 Mb
Chr 5:
140.76 – 140.83 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.[1][2][3]


Interactions[edit]

GNA12 has been shown to interact with ARHGEF1,[4] PPP5C,[5] ARHGEF12,[6][7] Heat shock protein 90kDa alpha (cytosolic), member A1[8] and TEC.[7]

See also[edit]

References[edit]

  1. ^ Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA (February 1993). "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product". Mol Cell Biol 13 (2): 762–8. PMC 358958. PMID 8423800. 
  2. ^ Kumar RN, Shore SK, Dhanasekaran N (February 2006). "Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3". Oncogene 25 (6): 899–906. doi:10.1038/sj.onc.1209132. PMID 16247467. 
  3. ^ "Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12". 
  4. ^ Johnson EN, Seasholtz TM, Waheed AA, et al. (December 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nat. Cell Biol. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662. 
  5. ^ Yamaguchi, Yoshiaki; Katoh Hironori; Mori Kazutoshi; Negishi Manabu (August 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Curr. Biol. (England) 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. ISSN 0960-9822. PMID 12176367. 
  6. ^ Fukuhara, S; Chikumi H; Gutkind J S (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Lett. (NETHERLANDS) 485 (2–3): 183–8. doi:10.1016/S0014-5793(00)02224-9. ISSN 0014-5793. PMID 11094164. 
  7. ^ a b Suzuki, Nobuchika; Nakamura Susumu; Mano Hiroyuki; Kozasa Tohru (January 2003). "Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (2): 733–8. doi:10.1073/pnas.0234057100. ISSN 0027-8424. PMC 141065. PMID 12515866. 
  8. ^ Vaiskunaite, R; Kozasa T; Voyno-Yasenetskaya T A (December 2001). "Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling". J. Biol. Chem. (United States) 276 (49): 46088–93. doi:10.1074/jbc.M108711200. ISSN 0021-9258. PMID 11598136. 

External links[edit]