GNA13

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Guanine nucleotide binding protein (G protein), alpha 13
Protein GNA13 PDB 1zcb.png
PDB rendering based on 1zcb.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GNA13 ; G13
External IDs OMIM604406 MGI95768 HomoloGene55976 GeneCards: GNA13 Gene
RNA expression pattern
PBB GE GNA13 206917 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10672 14674
Ensembl ENSG00000120063 ENSMUSG00000020611
UniProt Q14344 P27601
RefSeq (mRNA) NM_001282425 NM_010303
RefSeq (protein) NP_001269354 NP_034433
Location (UCSC) Chr 17:
63.01 – 63.05 Mb
Chr 11:
109.36 – 109.4 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein subunit alpha-13 is a protein that in humans is encoded by the GNA13 gene.[1][2]

Interactions[edit]

GNA13 has been shown to interact with ARHGEF1,[3][4][5] AKAP3,[6] RIC8A,[7] Radixin[8] and ARHGEF12.[9][10]

Clinical relevance[edit]

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[11][12]

See also[edit]

References[edit]

  1. ^ Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD (July 1995). "Expression of GTP-binding protein alpha subunits in human thymocytes". Mol Cell Biochem 144 (1): 45–51. doi:10.1007/BF00926739. PMID 7791744. 
  2. ^ "Entrez Gene: GNA13 guanine nucleotide binding protein (G protein), alpha 13". 
  3. ^ Johnson EN, Seasholtz TM, Waheed AA et al. (December 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nat. Cell Biol. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662. 
  4. ^ Bhattacharyya, Raja; Wedegaertner Philip B (April 2003). "Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment". FEBS Lett. (Netherlands) 540 (1–3): 211–6. doi:10.1016/S0014-5793(03)00267-9. ISSN 0014-5793. PMID 12681510. 
  5. ^ Hart, M J; Jiang X; Kozasa T; Roscoe W; Singer W D; Gilman A G; Sternweis P C; Bollag G (June 1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science (UNITED STATES) 280 (5372): 2112–4. doi:10.1126/science.280.5372.2112. ISSN 0036-8075. PMID 9641916. 
  6. ^ Niu, J; Vaiskunaite R; Suzuki N; Kozasa T; Carr D W; Dulin N; Voyno-Yasenetskaya T A (October 2001). "Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation". Curr. Biol. (England) 11 (21): 1686–90. doi:10.1016/S0960-9822(01)00530-9. ISSN 0960-9822. PMID 11696326. 
  7. ^ Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (March 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. (United States) 278 (10): 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430. 
  8. ^ Vaiskunaite, R; Adarichev V; Furthmayr H; Kozasa T; Gudkov A; Voyno-Yasenetskaya T A (August 2000). "Conformational activation of radixin by G13 protein alpha subunit". J. Biol. Chem. (UNITED STATES) 275 (34): 26206–12. doi:10.1074/jbc.M001863200. ISSN 0021-9258. PMID 10816569. 
  9. ^ Fukuhara, S; Chikumi H; Gutkind J S (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Lett. (NETHERLANDS) 485 (2–3): 183–8. doi:10.1016/S0014-5793(00)02224-9. ISSN 0014-5793. PMID 11094164. 
  10. ^ Suzuki, Nobuchika; Nakamura Susumu; Mano Hiroyuki; Kozasa Tohru (January 2003). "Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (2): 733–8. doi:10.1073/pnas.0234057100. ISSN 0027-8424. PMC 141065. PMID 12515866. 
  11. ^ Morin, Ryan D.; Mendez-Lago, Maria; Mungall, Andrew J.; Goya, Rodrigo; Mungall, Karen L.; Corbett, Richard D.; Johnson, Nathalie A.; Severson, Tesa M.; Chiu, Readman; Field, Matthew; Jackman, Shaun; Krzywinski, Martin; Scott, David W.; Trinh, Diane L.; Tamura-Wells, Jessica; Li, Sa; Firme, Marlo R.; Rogic, Sanja; Griffith, Malachi; Chan, Susanna; Yakovenko, Oleksandr; Meyer, Irmtraud M.; Zhao, Eric Y.; Smailus, Duane; Moksa, Michelle; Chittaranjan, Suganthi; Rimsza, Lisa; Brooks-Wilson, Angela; Spinelli, John J.; Ben-Neriah, Susana; Meissner, Barbara; Woolcock, Bruce; Boyle, Merrill; McDonald, Helen; Tam, Angela; Zhao, Yongjun; Delaney, Allen; Zeng, Thomas; Tse, Kane; Butterfield, Yaron; Birol, Inanç; Holt, Rob; Schein, Jacqueline; Horsman, Douglas E.; Moore, Richard; Jones, Steven J. M.; Connors, Joseph M.; Hirst, Martin; Gascoyne, Randy D.; Marra, Marco A. (2011). "Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma". Nature 476 (7360): 298–303. doi:10.1038/nature10351. ISSN 0028-0836. PMC 3210554. PMID 21796119. 
  12. ^ Lohr, JG; Stojanov, P, Lawrence, MS, Auclair, D, Chapuy, B, Sougnez, C, Cruz-Gordillo, P, Knoechel, B, Asmann, YW, Slager, SL, Novak, AJ, Dogan, A, Ansell, SM, Link, BK, Zou, L, Gould, J, Saksena, G, Stransky, N, Rangel-Escareño, C, Fernandez-Lopez, JC, Hidalgo-Miranda, A, Melendez-Zajgla, J, Hernández-Lemus, E, Schwarz-Cruz Y Celis, A, Imaz-Rosshandler, I, Ojesina, AI, Jung, J, Pedamallu, CS, Lander, ES, Habermann, TM, Cerhan, JR, Shipp, MA, Getz, G, Golub, TR (2012-02-17). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing.". Proceedings of the National Academy of Sciences of the United States of America 109 (10): 3879–84. doi:10.1073/pnas.1121343109. PMC 3309757. PMID 22343534. 

Further reading[edit]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.