GNAI1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Protein GNAI1 PDB 1agr.png
PDB rendering based on 1agr.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GNAI1 ; Gi
External IDs OMIM139310 MGI95771 HomoloGene74417 ChEMBL: 4741 GeneCards: GNAI1 Gene
RNA expression pattern
PBB GE GNAI1 209576 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2770 14677
Ensembl ENSG00000127955 ENSMUSG00000057614
UniProt P63096 B2RSH2
RefSeq (mRNA) NM_001256414 NM_010305
RefSeq (protein) NP_001243343 NP_034435
Location (UCSC) Chr 7:
79.76 – 79.85 Mb
Chr 5:
18.27 – 18.36 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.[1][2]


Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

[[File:
NicotineDopaminergic_WP1602 go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article Go to article Go to article go to article
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
[[
]]
NicotineDopaminergic_WP1602 go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article Go to article Go to article go to article
|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit|]]
Nicotine Activity on Dopaminergic Neurons edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602". 

Interactions[edit]

GNAI1 has been shown to interact with GPR143,[3] RGS14,[4][5] RIC8A,[6] S1PR1,[7] RGS12[4] and RGS19.[8][9]

References[edit]

  1. ^ Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M (August 1987). "Human cDNA clones for an alpha subunit of Gi signal-transduction protein". Proc Natl Acad Sci U S A 84 (15): 5115–9. doi:10.1073/pnas.84.15.5115. PMC 298804. PMID 3110783. 
  2. ^ "Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1". 
  3. ^ Schiaffino, M V; d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi M T, Colla C, De Luca M, Tacchetti C, Ballabio A (September 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system". Nat. Genet. (UNITED STATES) 23 (1): 108–12. doi:10.1038/12715. ISSN 1061-4036. PMID 10471510. 
  4. ^ a b Kimple, R J; De Vries L; Tronchère H; Behe C I; Morris R A; Gist Farquhar M; Siderovski D P (August 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. (United States) 276 (31): 29275–81. doi:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333. 
  5. ^ Kimple, Randall J; Kimple Michelle E; Betts Laurie; Sondek John; Siderovski David P (April 2002). "Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits". Nature (England) 416 (6883): 878–81. doi:10.1038/416878a. ISSN 0028-0836. PMID 11976690. 
  6. ^ Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (March 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. (United States) 278 (10): 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430. 
  7. ^ Lee, M J; Evans M; Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". J. Biol. Chem. (UNITED STATES) 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. ISSN 0021-9258. PMID 8626678. 
  8. ^ Woulfe, D S; Stadel J M (June 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. (UNITED STATES) 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. ISSN 0021-9258. PMID 10364213. 
  9. ^ De Vries, L; Elenko E; Hubler L; Jones T L; Farquhar M G (December 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of Gαi subunits". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. ISSN 0027-8424. PMC 26381. PMID 8986788. 

Further reading[edit]