GNAI1

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Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Protein GNAI1 PDB 1agr.png
PDB rendering based on 1agr.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GNAI1 ; Gi
External IDs OMIM139310 MGI95771 HomoloGene74417 ChEMBL: 4741 GeneCards: GNAI1 Gene
RNA expression pattern
PBB GE GNAI1 209576 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2770 14677
Ensembl ENSG00000127955 ENSMUSG00000057614
UniProt P63096 B2RSH2
RefSeq (mRNA) NM_001256414 NM_010305
RefSeq (protein) NP_001243343 NP_034435
Location (UCSC) Chr 7:
79.76 – 79.85 Mb
Chr 5:
18.27 – 18.36 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.[1][2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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NicotineDopaminergic_WP1602 go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article Go to article Go to article go to article
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NicotineDopaminergic_WP1602 go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article Go to article Go to article go to article
|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit||]]
Nicotine Activity on Dopaminergic Neurons edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602". 

Interactions[edit]

GNAI1 has been shown to interact with:

References[edit]

  1. ^ Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A et al. (Aug 1987). "Human cDNA clones for an alpha subunit of Gi signal-transduction protein". Proceedings of the National Academy of Sciences of the United States of America 84 (15): 5115–9. doi:10.1073/pnas.84.15.5115. PMC 298804. PMID 3110783. 
  2. ^ "Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1". 
  3. ^ Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K et al. (Sep 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system". Nature Genetics 23 (1): 108–12. doi:10.1038/12715. PMID 10471510. 
  4. ^ a b Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M et al. (Aug 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". The Journal of Biological Chemistry 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333. 
  5. ^ Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP (Apr 2002). "Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits". Nature 416 (6883): 878–81. doi:10.1038/416878a. PMID 11976690. 
  6. ^ Woulfe DS, Stadel JM (Jun 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". The Journal of Biological Chemistry 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. PMID 10364213. 
  7. ^ De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proceedings of the National Academy of Sciences of the United States of America 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788. 
  8. ^ Tall GG, Krumins AM, Gilman AG (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". The Journal of Biological Chemistry 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430. 
  9. ^ Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". The Journal of Biological Chemistry 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678. 

Further reading[edit]