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Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Symbols GNAI2 ; GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1
External IDs OMIM139360 MGI95772 HomoloGene55539 GeneCards: GNAI2 Gene
RNA expression pattern
PBB GE GNAI2 201040 at tn.png
More reference expression data
Species Human Mouse
Entrez 2771 14678
Ensembl ENSG00000114353 ENSMUSG00000032562
UniProt P04899 P08752
RefSeq (mRNA) NM_001166425 NM_008138
RefSeq (protein) NP_001159897 NP_032164
Location (UCSC) Chr 3:
50.23 – 50.26 Mb
Chr 9:
107.61 – 107.64 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein G(i), alpha-2 subunit is a protein that in humans is encoded by the GNAI2 gene.[1][2][3]


GNAI2 has been shown to interact with GPSM2,[4][5] RIC8A,[6] Interleukin 8 receptor, alpha,[7][8] EYA2,[9] RGS5[10][11] and MDFI.[12]


  1. ^ Didsbury JR, Ho YS, Snyderman R (March 1987). "Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA". FEBS Lett 211 (2): 160–4. doi:10.1016/0014-5793(87)81428-X. PMID 3100330. 
  2. ^ Magovcevic I, Ang SL, Seidman JG, Tolman CJ, Neer EJ, Morton CC (March 1992). "Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13". Genomics 12 (1): 125–9. doi:10.1016/0888-7543(92)90414-N. PMID 1733849. 
  3. ^ "Entrez Gene: GNAI2 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2". 
  4. ^ Marty, Caroline; Browning Darren D; Ye Richard D (June 2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. (United States) 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. ISSN 0270-7306. PMC 155206. PMID 12748287. 
  5. ^ Mochizuki, N; Cho G; Wen B; Insel P A (November 1996). "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2". Gene (NETHERLANDS) 181 (1–2): 39–43. doi:10.1016/S0378-1119(96)00456-8. ISSN 0378-1119. PMID 8973305. 
  6. ^ Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (March 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. (United States) 278 (10): 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430. 
  7. ^ Damaj, B B; McColl S R; Neote K; Songqing N; Ogborn K T; Hébert C A; Naccache P H (October 1996). "Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops". FASEB J. (UNITED STATES) 10 (12): 1426–34. ISSN 0892-6638. PMID 8903513. 
  8. ^ Damaj, B B; McColl S R; Mahana W; Crouch M F; Naccache P H (May 1996). "Physical association of Gi2alpha with interleukin-8 receptors". J. Biol. Chem. (UNITED STATES) 271 (22): 12783–9. doi:10.1074/jbc.271.22.12783. ISSN 0021-9258. PMID 8662698. 
  9. ^ Fan, X; Brass L F; Poncz M; Spitz F; Maire P; Manning D R (October 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. (UNITED STATES) 275 (41): 32129–34. doi:10.1074/jbc.M004577200. ISSN 0021-9258. PMID 10906137. 
  10. ^ Chen, C; Zheng B; Han J; Lin S C (March 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. (UNITED STATES) 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700. 
  11. ^ Zhou, J; Moroi K; Nishiyama M; Usui H; Seki N; Ishida J; Fukamizu A; Kimura S (February 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. (England) 68 (13): 1457–69. doi:10.1016/S0024-3205(01)00939-0. ISSN 0024-3205. PMID 11253162. 
  12. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

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