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Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
Protein GNAI3 PDB 1agr.png
PDB rendering based on 1agr.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GNAI3 ; 87U6; ARCND1
External IDs OMIM139370 MGI95773 HomoloGene55975 ChEMBL: 4221 GeneCards: GNAI3 Gene
RNA expression pattern
PBB GE GNAI3 201180 s at tn.png
PBB GE GNAI3 201179 s at tn.png
PBB GE GNAI3 201181 at tn.png
More reference expression data
Species Human Mouse
Entrez 2773 14679
Ensembl ENSG00000065135 ENSMUSG00000000001
UniProt P08754 Q9DC51
RefSeq (mRNA) NM_006496 NM_010306
RefSeq (protein) NP_006487 NP_034436
Location (UCSC) Chr 1:
110.09 – 110.14 Mb
Chr 3:
108.11 – 108.15 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 gene.[1][2]


GNAI3 has been shown to interact with RGS14,[3] RIC8A,[4] RGS18,[5][6] S1PR1,[7] RGS12,[3] RGS16,[8][9] RGS19,[10][11][12] RGS10[13] and RGS5.[8][14]

See also[edit]


  1. ^ Didsbury JR, Snyderman R (Aug 1987). "Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families". FEBS Lett 219 (1): 259–63. doi:10.1016/0014-5793(87)81228-0. PMID 3109953. 
  2. ^ "Entrez Gene: GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3". 
  3. ^ a b Kimple, R J; De Vries L; Tronchère H; Behe C I; Morris R A; Gist Farquhar M; Siderovski D P (Aug 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. (United States) 276 (31): 29275–81. doi:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333. 
  4. ^ Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. (United States) 278 (10): 8356–62. doi:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430. 
  5. ^ Yowe, D; Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie T M, Gutierrez-Ramos C, Hodge M R (Oct 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". Biochem. J. (England) 359 (Pt 1): 109–18. doi:10.1042/0264-6021:3590109. ISSN 0264-6021. PMC 1222126. PMID 11563974. 
  6. ^ Gagnon, Alison W; Murray David L; Leadley Robert J (Jul 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cell. Signal. (England) 14 (7): 595–606. doi:10.1016/S0898-6568(02)00012-8. ISSN 0898-6568. PMID 11955952. 
  7. ^ Lee, M J; Evans M; Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". J. Biol. Chem. (UNITED STATES) 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. ISSN 0021-9258. PMID 8626678. 
  8. ^ a b Chen, C; Zheng B; Han J; Lin S C (Mar 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. (UNITED STATES) 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700. 
  9. ^ Beadling, C; Druey K M; Richter G; Kehrl J H; Smith K A (Mar 1999). "Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes". J. Immunol. (UNITED STATES) 162 (5): 2677–82. ISSN 0022-1767. PMID 10072511. 
  10. ^ De Vries, L; Elenko E; Hubler L; Jones T L; Farquhar M G (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. ISSN 0027-8424. PMC 26381. PMID 8986788. 
  11. ^ Woulfe, D S; Stadel J M (Jun 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. (UNITED STATES) 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. ISSN 0021-9258. PMID 10364213. 
  12. ^ De Vries, L; Mousli M; Wurmser A; Farquhar M G (Dec 1995). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (25): 11916–20. doi:10.1073/pnas.92.25.11916. ISSN 0027-8424. PMC 40514. PMID 8524874. 
  13. ^ Hunt, T W; Fields T A; Casey P J; Peralta E G (Sep 1996). "RGS10 is a selective activator of G alpha i GTPase activity". Nature (ENGLAND) 383 (6596): 175–7. doi:10.1038/383175a0. ISSN 0028-0836. PMID 8774883. 
  14. ^ Zhou, J; Moroi K; Nishiyama M; Usui H; Seki N; Ishida J; Fukamizu A; Kimura S (Feb 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. (England) 68 (13): 1457–69. doi:10.1016/S0024-3205(01)00939-0. ISSN 0024-3205. PMID 11253162. 

Further reading[edit]