From Wikipedia, the free encyclopedia
Jump to: navigation, search
Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Symbols GNAO1 ; G-ALPHA-o; GNAO
External IDs OMIM139311 MGI95775 HomoloGene39203 ChEMBL: 4742 GeneCards: GNAO1 Gene
RNA expression pattern
PBB GE GNAO1 204762 s at tn.png
PBB GE GNAO1 204763 s at tn.png
PBB GE GNAO1 215912 at tn.png
More reference expression data
Species Human Mouse
Entrez 2775 14681
Ensembl ENSG00000087258 ENSMUSG00000031748
UniProt P09471 P18872
RefSeq (mRNA) NM_020988 NM_001113384
RefSeq (protein) NP_066268 NP_001106855
Location (UCSC) Chr 16:
56.23 – 56.39 Mb
Chr 8:
93.81 – 93.97 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene.[1][2][3]

Mutations in this gene have been shown to cause epileptic encephalopathy.[4]


GNAO1 has been shown to interact with:


  1. ^ Murtagh JJ Jr, Eddy R, Shows TB, Moss J, Vaughan M (Mar 1991). "Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16". Mol Cell Biol 11 (2): 1146–55. PMC 359797. PMID 1899283. 
  2. ^ Kinoshita M, Nukada T, Asano T, Mori Y, Akaike A, Satoh M, Kaneko S (Jul 2001). "Binding of G alpha(o) N terminus is responsible for the voltage-resistant inhibition of alpha(1A) (P/Q-type, Ca(v)2.1) Ca(2+) channels". J Biol Chem 276 (31): 28731–8. doi:10.1074/jbc.M104806200. PMID 11395521. 
  3. ^ "Entrez Gene: GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O". 
  4. ^ Nakamura K, Kodera H, Akita T, Shiina M, Kato M, Hoshino H, Terashima H, Osaka H, Nakamura S, Tohyama J, Kumada T, Furukawa T, Iwata S, Shiihara T, Kubota M, Miyatake S, Koshimizu E, Nishiyama K, Nakashima M, Tsurusaki Y, Miyake N, Hayasaka K, Ogata K, Fukuda A, Matsumoto N, Saitsu H (September 2013). "De Novo mutations in GNAO1, encoding a Gαo subunit of heterotrimeric G proteins, cause epileptic encephalopathy". Am. J. Hum. Genet. 93 (3): 496–505. doi:10.1016/j.ajhg.2013.07.014. PMID 23993195. 
  5. ^ Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. PMID 9079700. 
  6. ^ Zhou J, Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S (2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. 68 (13): 1457–69. doi:10.1016/S0024-3205(01)00939-0. PMID 11253162. 
  7. ^ De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788. 
  8. ^ Woulfe DS, Stadel JM (1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. PMID 10364213. 
  9. ^ Pagano M, Jordan JD, Neves SR, Nguyen T, Iyengar R (2008). "Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways". Cell. Signal. 20 (6): 1190–7. doi:10.1016/j.cellsig.2008.02.008. PMC 3107604. PMID 18407463. 
  10. ^ Tall GG, Krumins AM, Gilman AG (2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430. 

Further reading[edit]