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Guanine nucleotide binding protein (G protein), alpha z polypeptide
Symbol GNAZ
External IDs OMIM139160 MGI95780 HomoloGene22574 GeneCards: GNAZ Gene
RNA expression pattern
PBB GE GNAZ 204993 at tn.png
More reference expression data
Species Human Mouse
Entrez 2781 14687
Ensembl ENSG00000128266 ENSMUSG00000040009
UniProt P19086 O70443
RefSeq (mRNA) NM_002073 NM_010311
RefSeq (protein) NP_002064 NP_034441
Location (UCSC) Chr 22:
23.41 – 23.47 Mb
Chr 10:
74.97 – 75.02 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein G(z) subunit alpha is a protein that in humans is encoded by the GNAZ gene.[1][2]

The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systems. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids.[2]


GNAZ has been shown to interact with EYA2,[3] RGS20[4][5] and RGS19.[3][6]


  1. ^ Matsuoka M, Itoh H, Kaziro Y (September 1990). "Characterization of the human gene for Gx alpha, a pertussis toxin-insensitive regulatory GTP-binding protein". J Biol Chem 265 (22): 13215–20. PMID 2115889. 
  2. ^ a b "Entrez Gene: GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide". 
  3. ^ a b Fan, X; Brass L F; Poncz M; Spitz F; Maire P; Manning D R (October 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. (United States) 275 (41): 32129–34. doi:10.1074/jbc.M004577200. ISSN 0021-9258. PMID 10906137. 
  4. ^ Nagahama, Masami; Usui Shihomi; Shinohara Takashi; Yamaguchi Tomohiro; Tani Katsuko; Tagaya Mitsuo (December 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus". J. Cell. Sci. (England) 115 (Pt 23): 4483–93. doi:10.1242/jcs.00093. ISSN 0021-9533. PMID 12414994. 
  5. ^ Glick, J L; Meigs T E; Miron A; Casey P J (October 1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha". J. Biol. Chem. (United States) 273 (40): 26008–13. doi:10.1074/jbc.273.40.26008. ISSN 0021-9258. PMID 9748279. 
  6. ^ De Vries, L; Elenko E; Hubler L; Jones T L; Farquhar M G (December 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. (United States) 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. ISSN 0027-8424. PMC 26381. PMID 8986788. 

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