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Guanine nucleotide binding protein (G protein), alpha z polypeptide
Symbol GNAZ
External IDs OMIM139160 MGI95780 HomoloGene22574 GeneCards: GNAZ Gene
RNA expression pattern
PBB GE GNAZ 204993 at tn.png
More reference expression data
Species Human Mouse
Entrez 2781 14687
Ensembl ENSG00000128266 ENSMUSG00000040009
UniProt P19086 O70443
RefSeq (mRNA) NM_002073 NM_010311
RefSeq (protein) NP_002064 NP_034441
Location (UCSC) Chr 22:
23.41 – 23.47 Mb
Chr 10:
74.97 – 75.02 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein G(z) subunit alpha is a protein that in humans is encoded by the GNAZ gene.[1][2]


The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systems. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids.[2]


GNAZ has been shown to interact with EYA2,[3] RGS20[4][5] and RGS19.[3][6]


  1. ^ Matsuoka M, Itoh H, Kaziro Y (September 1990). "Characterization of the human gene for Gx alpha, a pertussis toxin-insensitive regulatory GTP-binding protein". J. Biol. Chem. 265 (22): 13215–20. PMID 2115889. 
  2. ^ a b "Entrez Gene: GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide". 
  3. ^ a b Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR (October 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. 275 (41): 32129–34. doi:10.1074/jbc.M004577200. PMID 10906137. 
  4. ^ Nagahama M, Usui S, Shinohara T, Yamaguchi T, Tani K, Tagaya M (December 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus". J. Cell. Sci. 115 (Pt 23): 4483–93. doi:10.1242/jcs.00093. PMID 12414994. 
  5. ^ Glick JL, Meigs TE, Miron A, Casey PJ (October 1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha". J. Biol. Chem. 273 (40): 26008–13. doi:10.1074/jbc.273.40.26008. PMID 9748279. 
  6. ^ De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (December 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788. 

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