GNB1

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Guanine nucleotide binding protein (G protein), beta polypeptide 1
Protein GNB1 PDB 1a0r.png
PDB rendering based on 1a0r.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol GNB1
External IDs OMIM139380 MGI95781 HomoloGene55532 GeneCards: GNB1 Gene
RNA expression pattern
PBB GE GNB1 200745 s at tn.png
PBB GE GNB1 200744 s at tn.png
PBB GE GNB1 200746 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2782 14688
Ensembl ENSG00000078369 ENSMUSG00000029064
UniProt P62873 P62874
RefSeq (mRNA) NM_002074 NM_001160016
RefSeq (protein) NP_002065 NP_001153488
Location (UCSC) Chr 1:
1.72 – 1.82 Mb
Chr 4:
155.49 – 155.56 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene.[1]

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.[1]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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NicotineDopaminergic_WP1602 go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article Go to article Go to article go to article
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Nicotine Activity on Dopaminergic Neurons edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602". 

Interactions[edit]

GNB1 has been shown to interact with GNG4.[2][3]

References[edit]

  1. ^ a b "Entrez Gene: GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1". 
  2. ^ Ray, K; Kunsch C; Bonner L M; Robishaw J D (September 1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J. Biol. Chem. (UNITED STATES) 270 (37): 21765–71. doi:10.1074/jbc.270.37.21765. ISSN 0021-9258. PMID 7665596. 
  3. ^ Yan, K; Kalyanaraman V; Gautam N (March 1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. (UNITED STATES) 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. ISSN 0021-9258. PMID 8636150. 

Further reading[edit]