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Guanine nucleotide binding protein (G protein), beta 5
Symbols GNB5 ; GB5
External IDs OMIM604447 MGI101848 HomoloGene40714 GeneCards: GNB5 Gene
RNA expression pattern
PBB GE GNB5 207124 s at tn.png
PBB GE GNB5 204000 at tn.png
PBB GE GNB5 211871 x at tn.png
More reference expression data
Species Human Mouse
Entrez 10681 14697
Ensembl ENSG00000069966 ENSMUSG00000032192
UniProt O14775 P62881
RefSeq (mRNA) NM_006578 NM_010313
RefSeq (protein) NP_006569 NP_034443
Location (UCSC) Chr 15:
52.41 – 52.48 Mb
Chr 9:
75.31 – 75.34 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene.[1] Alternatively spliced transcript variants encoding different isoforms exist.[2]


Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.[2]

GNB5 has been shown to differentially control RGS protein stability and membrane anchor binding, and therefor is involved in the control of complex neuronal G protein signaling pathways.[3]


GNB5 has been shown to interact with:


  1. ^ Jones PG, Lombardi SJ, Cockett MI (Jun 1998). "Cloning and tissue distribution of the human G protein beta 5 cDNA". Biochim. Biophys. Acta 1402 (3): 288–91. doi:10.1016/S0167-4889(98)00017-2. PMID 9606987. 
  2. ^ a b "Entrez Gene: GNB5 guanine nucleotide binding protein (G protein), beta 5". 
  3. ^ a b Masuho I, Wakasugi-Masuho H, Posokhova EN, Patton JR, Martemyanov KA (June 2011). "Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors". J. Biol. Chem. 286 (24): 21806–13. doi:10.1074/jbc.M111.241513. PMC 3122235. PMID 21511947. 
  4. ^ Yan K, Kalyanaraman V, Gautam N (March 1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150. 
  5. ^ Blake BL, Wing MR, Zhou JY, Lei Q, Hillmann JR, Behe CI et al. (December 2001). "G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13)". J. Biol. Chem. 276 (52): 49267–74. doi:10.1074/jbc.M106565200. PMID 11675383. 
  6. ^ Levay K, Cabrera JL, Satpaev DK, Slepak VZ (March 1999). "Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. doi:10.1073/pnas.96.5.2503. PMC 26814. PMID 10051672. 
  7. ^ Posner BA, Gilman AG, Harris BA (October 1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. PMID 10521509. 

Further reading[edit]