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GNC may refer to:
- GNC (store) (General Nutrition Centers), an American retail company
- General National Congress, the legislative authority of Libya
- Gibraltar Nynex Communications, a former telecommunications operator in Gibraltar, now part of Gibtelecom
- Global Night Commute, an Invisible Children event which took place on 29 April 2006
- Guagua National Colleges a private school in Pampanga, Philippines
- Guidance, navigation and control (also written "GN&C")
- GNC, stockticker symbol for Greencore
- gnc, ISO 639-3 language code for the Guanche language
- Geographical Names Committee, one of several Chinese organizations to adopt SASM/GNC romanization
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